BDBM50140098 1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-3-{(S)-2-[(3-methyl-thiophen-2-ylmethyl)-amino]-propyl}-1H-pyrimidine-2,4-dione::CHEMBL283381
SMILES: COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](C)NCc2sccc2C)c1=O
InChI Key: InChIKey=UOSJSHOYCNDHMM-KRWDZBQOSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM50140098 (1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc. Curated by ChEMBL | Assay Description Binding affinity evaluated by the ability to inhibit des-Gly10[125I]Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]- Gonadotropin-releasing hormone binding to cloned h... | J Med Chem 47: 1259-71 (2004) Article DOI: 10.1021/jm030472z BindingDB Entry DOI: 10.7270/Q2KD1ZNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM50140098 (1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 87 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc. Curated by ChEMBL | Assay Description In vivo inhibition of monkey Gonadotropin-releasing hormone receptor | J Med Chem 47: 1259-71 (2004) Article DOI: 10.1021/jm030472z BindingDB Entry DOI: 10.7270/Q2KD1ZNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gonadotropin-releasing hormone receptor (Rattus norvegicus) | BDBM50140098 (1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc. Curated by ChEMBL | Assay Description In vivo inhibition of rat Gonadotropin-releasing hormone receptor | J Med Chem 47: 1259-71 (2004) Article DOI: 10.1021/jm030472z BindingDB Entry DOI: 10.7270/Q2KD1ZNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM50140098 (1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc. Curated by ChEMBL | Assay Description In vitro inhibition of [Ca2+] influx in RBL cells expressing Gonadotropin-releasing hormone receptor | J Med Chem 47: 1259-71 (2004) Article DOI: 10.1021/jm030472z BindingDB Entry DOI: 10.7270/Q2KD1ZNH | |||||||||||
More data for this Ligand-Target Pair |