BindingDB PrimarySearch

BDBM50140257 5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one::5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one(Wogonin)::5,7-dihydroxy-8-methoxyflavone::CHEMBL16171::WOGONIN

SMILES: COc1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1

InChI Key: InChIKey=XLTFNNCXVBYBSX-UHFFFAOYSA-N

Data: 15 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50140257
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50140257 (5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one \| 5...) Show SMILES COc1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Tom's of Maine Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells				J Nat Prod 66: 535-7 (2003) Article DOI: 10.1021/np0205102 BindingDB Entry DOI: 10.7270/Q2CZ36WZ
Tom's of Maine Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9) (Homo sapiens (Human))	BDBM50140257 (5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one \| 5...) Show SMILES COc1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human recombinant N-terminal GST-tagged CDK9 (2 to 372 residues) expressed in baculovirus infected Sf9 insect cells co-expressing human...				Bioorg Med Chem 27: 677-685 (2019) Article DOI: 10.1016/j.bmc.2019.01.027
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclooxygenase (Homo sapiens (Human))	BDBM50140257 (5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one \| 5...) Show SMILES COc1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Guru Nanak Dev University Curated by ChEMBL					Assay Description Inhibition of human recombinant COX-2 assessed as PGF2 alpha formation using arachidonic acid as substrate pretreated with compound for 20 mins prior...				Eur J Med Chem 97: 104-23 (2015) Article DOI: 10.1016/j.ejmech.2015.04.044 BindingDB Entry DOI: 10.7270/Q2N87CJN
Guru Nanak Dev University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclooxygenase-2 (COX-2) (Mus musculus (Mouse))	BDBM50140257 (5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one \| 5...) Show SMILES COc1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Medicine and Pharmacy at Ho Chi Minh City Curated by ChEMBL					Assay Description Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW264.7 cells by enzyme immunoassay				Bioorg Med Chem Lett 19: 1650-3 (2009) Article DOI: 10.1016/j.bmcl.2009.02.001 BindingDB Entry DOI: 10.7270/Q28052HJ
					More data for this Ligand-Target Pair
Xanthine dehydrogenase (Bos taurus (Bovine))	BDBM50140257 (5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one \| 5...) Show SMILES COc1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.76E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of cow milk xanthine oxidase				J Nat Prod 51: 345-348 (1988) Article DOI: 10.1021/np50056a030 BindingDB Entry DOI: 10.7270/Q2DJ5FNN
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclooxygenase (Homo sapiens (Human))	BDBM50140257 (5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one \| 5...) Show SMILES COc1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Inhibition of COX2				J Nat Prod 68: 985-91 (2005) Article DOI: 10.1021/np049655u BindingDB Entry DOI: 10.7270/Q27S7PN5
Uppsala University Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric Oxide Synthase, inducible (Mus musculus (mouse))	BDBM50140257 (5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one \| 5...) Show SMILES COc1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of iNOS-induced NO production in LPS-stimulated mouse BV2 cells after 24 hrs				Bioorg Med Chem Lett 22: 2534-5 (2012) Article DOI: 10.1016/j.bmcl.2012.01.135 BindingDB Entry DOI: 10.7270/Q2Q52QNT
Kangwon National University Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM50140257 (5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one \| 5...) Show SMILES COc1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.87E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of LSD1 (unknown origin)				Bioorg Med Chem 27: 370-374 (2019) Article DOI: 10.1016/j.bmc.2018.12.013
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Trypsin (Homo sapiens (Human))	BDBM50140257 (5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one \| 5...) Show SMILES COc1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.05E+5	n/a	n/a	n/a	n/a	n/a	n/a
Ehime University Curated by ChEMBL					Assay Description Inhibition of trypsin-induced elevation in PAI1 production in HUVEC by ELISA				J Nat Prod 60: 598-601 (1997) Article DOI: 10.1021/np970035l BindingDB Entry DOI: 10.7270/Q20C4ZK4
Ehime University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9) (Homo sapiens (Human))	BDBM50140257 (5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one \| 5...) Show SMILES COc1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	198	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human CDK9/cyclin-T1 using YSPTSPSYSPTSPSYSPTSPKKK peptide as substrate after 2 hrs by [gamma-33P]-ATP assay				Eur J Med Chem 178: 782-801 (2019) Article DOI: 10.1016/j.ejmech.2019.06.024
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 2 (CDK2) (Homo sapiens (Human))	BDBM50140257 (5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one \| 5...) Show SMILES COc1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.46E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human CDK2/cyclin-A2 using H1 histone as substrate after 2 hrs by [gamma-33P]-ATP assay				Eur J Med Chem 178: 782-801 (2019) Article DOI: 10.1016/j.ejmech.2019.06.024
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9) (Homo sapiens (Human))	BDBM50140257 (5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one \| 5...) Show SMILES COc1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human recombinant N-terminal GST-tagged CDK9 (2 to 372 residues)/N-terminal GST-tagged cyclin-T1 (2 to 726 residues) expressed in bacul...				Eur J Med Chem 178: 782-801 (2019) Article DOI: 10.1016/j.ejmech.2019.06.024
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
CDK7/Cyclin H/MNAT1 (Homo sapiens (Human))	BDBM50140257 (5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one \| 5...) Show SMILES COc1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.23E+4	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human full length C-terminal His6-tagged and N-terminal GST-tagged CDK7/cyclinH/MAT1 expressed in baculovirus Sf21 insect c...				Bioorg Med Chem 27: 677-685 (2019) Article DOI: 10.1016/j.bmc.2019.01.027
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50140257 (5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one \| 5...) Show SMILES COc1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.46E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of CDK2 (unknown origin)				Bioorg Med Chem 27: 677-685 (2019) Article DOI: 10.1016/j.bmc.2019.01.027
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclooxygenase (Homo sapiens (Human))	BDBM50140257 (5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one \| 5...) Show SMILES COc1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Guru Nanak Dev University Curated by ChEMBL					Assay Description Inhibition of human recombinant COX-2 assessed as decrease in prostaglandin production using arachidonic acid as substrate incubated with enzyme for ...				Eur J Med Chem 77: 185-92 (2014) Article DOI: 10.1016/j.ejmech.2014.03.003 BindingDB Entry DOI: 10.7270/Q2319XH6
Guru Nanak Dev University Curated by ChEMBL					More data for this Ligand-Target Pair