null

SMILES: O=S(=O)(Cc1ccccc1)Nc1ncnc2c(C#N)c3CCCCn3c12

InChI Key: InChIKey=KFQUMKPKLQOAFG-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50140827   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ATP-dependent translocase ABCB1 (Mus musculus)	BDBM50140827 (CHEMBL27524 | N-(10-Cyano-6,7,8,9-tetrahydro-pyrim...) Show SMILES O=S(=O)(Cc1ccccc1)Nc1ncnc2c(C#N)c3CCCCn3c12 Show InChI InChI=1S/C18H17N5O2S/c19-10-14-15-8-4-5-9-23(15)17-16(14)20-12-21-18(17)22-26(24,25)11-13-6-2-1-3-7-13/h1-3,6-7,12H,4-5,8-9,11H2,(H,20,21,22)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Xenova Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against mouse transporter Pgp (P-glycoprotein) expressed in EMT6/AR1.0 cell line				J Med Chem 47: 1329-38 (2004) Article DOI: 10.1021/jm031011g BindingDB Entry DOI: 10.7270/Q25Q4VH0
					More data for this Ligand-Target Pair
Multidrug resistance-associated protein 1 (Homo sapiens (Human))	BDBM50140827 (CHEMBL27524 | N-(10-Cyano-6,7,8,9-tetrahydro-pyrim...) Show SMILES O=S(=O)(Cc1ccccc1)Nc1ncnc2c(C#N)c3CCCCn3c12 Show InChI InChI=1S/C18H17N5O2S/c19-10-14-15-8-4-5-9-23(15)17-16(14)20-12-21-18(17)22-26(24,25)11-13-6-2-1-3-7-13/h1-3,6-7,12H,4-5,8-9,11H2,(H,20,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.09E+4	n/a	n/a	n/a	n/a	n/a	n/a
Xenova Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line				J Med Chem 47: 1329-38 (2004) Article DOI: 10.1021/jm031011g BindingDB Entry DOI: 10.7270/Q25Q4VH0
					More data for this Ligand-Target Pair