BDBM50141585 4-(3-Chloro-4-methoxy-benzylamino)-6-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester::CHEMBL42869
SMILES: CCOC(=O)c1cnc2ccc(cc2c1NCc1ccc(OC)c(Cl)c1)C(F)(F)F
InChI Key: InChIKey=KVNCMWLMNCGOGL-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM50141585 (4-(3-Chloro-4-methoxy-benzylamino)-6-trifluorometh...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of phosphodiesterase 5 from human platelets | Bioorg Med Chem Lett 14: 1577-80 (2004) Article DOI: 10.1016/j.bmcl.2003.12.090 BindingDB Entry DOI: 10.7270/Q2G1607Q | |||||||||||
More data for this Ligand-Target Pair |