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SMILES: CC1(C)OCc2c1nc(nc2Nc1n[nH]c2cc(ccc12)C(F)(F)F)-c1cn[nH]c1

InChI Key: InChIKey=IUODVBYYCGATTD-UHFFFAOYSA-N

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50141671   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2/Receptor tyrosine-protein kinase erbB-3/Receptor tyrosine-protein kinase erbB-4


(Homo sapiens (Human))		BDBM50141671
PNG
(CHEMBL3758871)
Show SMILES CC1(C)OCc2c1nc(nc2Nc1n[nH]c2cc(ccc12)C(F)(F)F)-c1cn[nH]c1
Show InChI InChI=1S/C19H16F3N7O/c1-18(2)14-12(8-30-18)16(26-15(25-14)9-6-23-24-7-9)27-17-11-4-3-10(19(20,21)22)5-13(11)28-29-17/h3-7H,8H2,1-2H3,(H,23,24)(H2,25,26,27,28,29)
PDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
PubMed
>2.00E+3n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of EGFR T790M/L858R mutant (unknown origin)

Bioorg Med Chem Lett 26: 534-9 (2016)


BindingDB Entry DOI: 10.7270/Q2HH6MZQ
More data for this
Ligand-Target Pair