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SMILES: COc1cc2nccc(Oc3ccc(NC4CCC(CC4)C(C)(C)C)cc3)c2cc1OC

InChI Key: InChIKey=MGGAROKMOBSMTE-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50141828   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM50141828
PNG
((4-tert-Butyl-cyclohexyl)-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC4CCC(CC4)C(C)(C)C)cc3)c2cc1OC |(1.64,-5.73,;2.98,-6.5,;4.31,-5.73,;5.66,-6.49,;6.98,-5.73,;8.31,-6.49,;9.65,-5.73,;9.65,-4.19,;8.31,-3.42,;8.31,-1.89,;9.64,-1.12,;9.64,.43,;10.96,1.2,;12.3,.43,;13.64,1.21,;14.98,.44,;16.3,1.23,;17.65,.46,;17.67,-1.08,;16.32,-1.86,;14.99,-1.09,;19.03,-1.85,;20.39,-2.59,;19.79,-.49,;18.28,-3.2,;12.3,-1.12,;10.96,-1.89,;6.98,-4.19,;5.66,-3.42,;4.31,-4.19,;2.98,-3.42,;1.65,-4.2,)|
Show InChI InChI=1S/C27H34N2O3/c1-27(2,3)18-6-8-19(9-7-18)29-20-10-12-21(13-11-20)32-24-14-15-28-23-17-26(31-5)25(30-4)16-22(23)24/h10-19,29H,6-9H2,1-5H3
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MMDB

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n/an/a 3.40E+3n/an/an/an/an/an/a



Kirin Brewery Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell line

Bioorg Med Chem Lett 14: 875-9 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.019
BindingDB Entry DOI: 10.7270/Q2TB16BV
More data for this
Ligand-Target Pair