BDBM50142136 5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-guanidinomethyl-benzoylamino)-benzamide::CHEMBL177444

SMILES: NC(=N)NCc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1

InChI Key: InChIKey=LYOKSLMCVXCMIB-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50142136   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vitamin K-dependent protein C (Homo sapiens (Human))	BDBM50142136 (5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-guanidinom...) Show SMILES NC(=N)NCc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C21H18Cl2N6O2/c22-14-5-7-17(16(9-14)20(31)29-18-8-6-15(23)11-26-18)28-19(30)13-3-1-12(2-4-13)10-27-21(24)25/h1-9,11H,10H2,(H,28,30)(H4,24,25,27)(H,26,29,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against activated protein C				Bioorg Med Chem Lett 14: 989-93 (2004) Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD
					More data for this Ligand-Target Pair
Trypsin-1 (Homo sapiens (Human))	BDBM50142136 (5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-guanidinom...) Show SMILES NC(=N)NCc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C21H18Cl2N6O2/c22-14-5-7-17(16(9-14)20(31)29-18-8-6-15(23)11-26-18)28-19(30)13-3-1-12(2-4-13)10-27-21(24)25/h1-9,11H,10H2,(H,28,30)(H4,24,25,27)(H,26,29,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against trypsin.				Bioorg Med Chem Lett 14: 989-93 (2004) Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50142136 (5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-guanidinom...) Show SMILES NC(=N)NCc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C21H18Cl2N6O2/c22-14-5-7-17(16(9-14)20(31)29-18-8-6-15(23)11-26-18)28-19(30)13-3-1-12(2-4-13)10-27-21(24)25/h1-9,11H,10H2,(H,28,30)(H4,24,25,27)(H,26,29,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against thrombin.				Bioorg Med Chem Lett 14: 989-93 (2004) Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM50142136 (5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-guanidinom...) Show SMILES NC(=N)NCc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C21H18Cl2N6O2/c22-14-5-7-17(16(9-14)20(31)29-18-8-6-15(23)11-26-18)28-19(30)13-3-1-12(2-4-13)10-27-21(24)25/h1-9,11H,10H2,(H,28,30)(H4,24,25,27)(H,26,29,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against coagulation factor X.				Bioorg Med Chem Lett 14: 989-93 (2004) Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD
					More data for this Ligand-Target Pair
Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM50142136 (5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-guanidinom...) Show SMILES NC(=N)NCc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C21H18Cl2N6O2/c22-14-5-7-17(16(9-14)20(31)29-18-8-6-15(23)11-26-18)28-19(30)13-3-1-12(2-4-13)10-27-21(24)25/h1-9,11H,10H2,(H,28,30)(H4,24,25,27)(H,26,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against tissue type plasminogen activator.				Bioorg Med Chem Lett 14: 989-93 (2004) Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50142136 (5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-guanidinom...) Show SMILES NC(=N)NCc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C21H18Cl2N6O2/c22-14-5-7-17(16(9-14)20(31)29-18-8-6-15(23)11-26-18)28-19(30)13-3-1-12(2-4-13)10-27-21(24)25/h1-9,11H,10H2,(H,28,30)(H4,24,25,27)(H,26,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against plasmin.				Bioorg Med Chem Lett 14: 989-93 (2004) Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD
					More data for this Ligand-Target Pair