BindingDB PrimarySearch

BDBM50142448 (S)-1-(3-(3-(4-fluorobenzyl)piperidin-1-yl)propyl)-3-(3-acetylphenyl)urea::1-(3-Acetyl-phenyl)-3-{3-[(S)-3-(4-fluoro-benzyl)-piperidin-1-yl]-propyl}-urea::CHEMBL46905

SMILES: CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1

InChI Key: InChIKey=FDDSQKZQCHXOJV-FQEVSTJZSA-N

Data: 1 KI 6 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50142448
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50142448 ((S)-1-(3-(3-(4-fluorobenzyl)piperidin-1-yl)propyl)...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.35E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]-eotaxin binding to serotonin 5-hydroxytryptamine 2A receptor				Bioorg Med Chem Lett 14: 1645-9 (2004) Article DOI: 10.1016/j.bmcl.2004.01.059 BindingDB Entry DOI: 10.7270/Q2RB741N
					More data for this Ligand-Target Pair
C-C chemokine receptor type 3 (Homo sapiens (Human))	BDBM50142448 ((S)-1-(3-(3-(4-fluorobenzyl)piperidin-1-yl)propyl)...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]-eotaxin.				Bioorg Med Chem Lett 14: 1645-9 (2004) Article DOI: 10.1016/j.bmcl.2004.01.059 BindingDB Entry DOI: 10.7270/Q2RB741N
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50142448 ((S)-1-(3-(3-(4-fluorobenzyl)piperidin-1-yl)propyl)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Inhibition of CYP2D6				Bioorg Med Chem Lett 18: 576-85 (2008) Article DOI: 10.1016/j.bmcl.2007.11.067 BindingDB Entry DOI: 10.7270/Q2057GS3
Bristol-Myers Squibb Company Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 3 (Homo sapiens (Human))	BDBM50142448 ((S)-1-(3-(3-(4-fluorobenzyl)piperidin-1-yl)propyl)...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells				Bioorg Med Chem Lett 18: 576-85 (2008) Article DOI: 10.1016/j.bmcl.2007.11.067 BindingDB Entry DOI: 10.7270/Q2057GS3
Bristol-Myers Squibb Company Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 3 (Homo sapiens (Human))	BDBM50142448 ((S)-1-(3-(3-(4-fluorobenzyl)piperidin-1-yl)propyl)...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis				Bioorg Med Chem Lett 18: 576-85 (2008) Article DOI: 10.1016/j.bmcl.2007.11.067 BindingDB Entry DOI: 10.7270/Q2057GS3
Bristol-Myers Squibb Company Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 3 (Homo sapiens (Human))	BDBM50142448 ((S)-1-(3-(3-(4-fluorobenzyl)piperidin-1-yl)propyl)...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells				J Med Chem 48: 2194-211 (2005) Article DOI: 10.1021/jm049530m BindingDB Entry DOI: 10.7270/Q2XP74F1
Pharmaceutical Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 3 (Homo sapiens (Human))	BDBM50142448 ((S)-1-(3-(3-(4-fluorobenzyl)piperidin-1-yl)propyl)...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of eotaxin-induced chemotaxis of human eosinophils				J Med Chem 48: 2194-211 (2005) Article DOI: 10.1021/jm049530m BindingDB Entry DOI: 10.7270/Q2XP74F1
Pharmaceutical Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair