BDBM50142516 Acetic acid 4-[3-(4-acetoxy-benzoylamino)-phenylcarbamoyl]-phenyl ester::CHEMBL296856

SMILES: CC(=O)Oc1ccc(cc1)C(=O)Nc1cccc(NC(=O)c2ccc(OC(C)=O)cc2)c1

InChI Key: InChIKey=YJSFCFUKKGRYIS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50142516   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase I (Topo I) (Homo sapiens (Human))	BDBM50142516 (Acetic acid 4-[3-(4-acetoxy-benzoylamino)-phenylca...) Show SMILES CC(=O)Oc1ccc(cc1)C(=O)Nc1cccc(NC(=O)c2ccc(OC(C)=O)cc2)c1 Show InChI InChI=1S/C24H20N2O6/c1-15(27)31-21-10-6-17(7-11-21)23(29)25-19-4-3-5-20(14-19)26-24(30)18-8-12-22(13-9-18)32-16(2)28/h3-14H,1-2H3,(H,25,29)(H,26,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Kumamoto University Curated by ChEMBL					Assay Description Inhibitory concentration against relaxation activity of DNA topoisomerase I by detecting the conversion of supercoiled pBR322 DNA to its relaxed form				Bioorg Med Chem Lett 14: 1669-72 (2004) Article DOI: 10.1016/j.bmcl.2004.01.060 BindingDB Entry DOI: 10.7270/Q2GX4B0X
					More data for this Ligand-Target Pair