BDBM50143652 8-{2-[4-(2-Chloro-phenyl)-piperidin-1-yl]-ethyl}-8-aza-spiro[4.5]decane-7,9-dione::CHEMBL56292

SMILES: Clc1ccccc1C1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1

InChI Key: InChIKey=QGNJCJCADQNVJR-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50143652   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Alpha-1D adrenergic receptor (Rattus norvegicus (Rat))	BDBM50143652 (8-{2-[4-(2-Chloro-phenyl)-piperidin-1-yl]-ethyl}-8...) Show SMILES Clc1ccccc1C1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 Show InChI InChI=1S/C22H29ClN2O2/c23-19-6-2-1-5-18(19)17-7-11-24(12-8-17)13-14-25-20(26)15-22(16-21(25)27)9-3-4-10-22/h1-2,5-6,17H,3-4,7-16H2	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Recordati s.p.a. Curated by ChEMBL					Assay Description Binding affinity to the adrenergic receptor alpha-1D of rat aorta				J Med Chem 47: 1900-18 (2004) Article DOI: 10.1021/jm030944+ BindingDB Entry DOI: 10.7270/Q23F4P35
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM50143652 (8-{2-[4-(2-Chloro-phenyl)-piperidin-1-yl]-ethyl}-8...) Show SMILES Clc1ccccc1C1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 Show InChI InChI=1S/C22H29ClN2O2/c23-19-6-2-1-5-18(19)17-7-11-24(12-8-17)13-14-25-20(26)15-22(16-21(25)27)9-3-4-10-22/h1-2,5-6,17H,3-4,7-16H2	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.01	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Recordati s.p.a. Curated by ChEMBL					Assay Description In vitro binding affinity towards alpha-1A adrenergic receptor through displacement of [3H]-prazosin in epididymal rat vas deferens.				J Med Chem 47: 1900-18 (2004) Article DOI: 10.1021/jm030944+ BindingDB Entry DOI: 10.7270/Q23F4P35
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50143652 (8-{2-[4-(2-Chloro-phenyl)-piperidin-1-yl]-ethyl}-8...) Show SMILES Clc1ccccc1C1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 Show InChI InChI=1S/C22H29ClN2O2/c23-19-6-2-1-5-18(19)17-7-11-24(12-8-17)13-14-25-20(26)15-22(16-21(25)27)9-3-4-10-22/h1-2,5-6,17H,3-4,7-16H2	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Recordati s.p.a. Curated by ChEMBL					Assay Description Binding affinity to human 5-hydroxytryptamine 1A receptor was measured using [3H]-8-hydroxy-2-(di-n-propylamine) tetraline [3H]-8-OH-DPAT) as radioli...				J Med Chem 47: 1900-18 (2004) Article DOI: 10.1021/jm030944+ BindingDB Entry DOI: 10.7270/Q23F4P35
					More data for this Ligand-Target Pair
Adrenergic alpha1B (Homo sapiens (Human))	BDBM50143652 (8-{2-[4-(2-Chloro-phenyl)-piperidin-1-yl]-ethyl}-8...) Show SMILES Clc1ccccc1C1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 Show InChI InChI=1S/C22H29ClN2O2/c23-19-6-2-1-5-18(19)17-7-11-24(12-8-17)13-14-25-20(26)15-22(16-21(25)27)9-3-4-10-22/h1-2,5-6,17H,3-4,7-16H2	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.76	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Recordati s.p.a. Curated by ChEMBL					Assay Description Binding affinity constant against alpha-1B adrenergic receptor of guinea pig spleen				J Med Chem 47: 1900-18 (2004) Article DOI: 10.1021/jm030944+ BindingDB Entry DOI: 10.7270/Q23F4P35
					More data for this Ligand-Target Pair