BDBM50143681 8-{2-[4-(2-Cyclopropyl-phenyl)-piperazin-1-yl]-ethyl}-8-aza-spiro[4.5]decane-7,9-dione::CHEMBL56804

SMILES: O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(CC1)c1ccccc1C1CC1

InChI Key: InChIKey=IXXRJDPEMQTXTR-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50143681   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50143681 (8-{2-[4-(2-Cyclopropyl-phenyl)-piperazin-1-yl]-eth...) Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(CC1)c1ccccc1C1CC1 Show InChI InChI=1S/C24H33N3O2/c28-22-17-24(9-3-4-10-24)18-23(29)27(22)16-13-25-11-14-26(15-12-25)21-6-2-1-5-20(21)19-7-8-19/h1-2,5-6,19H,3-4,7-18H2	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Recordati s.p.a. Curated by ChEMBL					Assay Description Binding affinity to human 5-hydroxytryptamine 1A receptor was measured using [3H]-8-hydroxy-2-(di-n-propylamine) tetraline [3H]-8-OH-DPAT) as radioli...				J Med Chem 47: 1900-18 (2004) Article DOI: 10.1021/jm030944+ BindingDB Entry DOI: 10.7270/Q23F4P35
					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Rattus norvegicus (Rat))	BDBM50143681 (8-{2-[4-(2-Cyclopropyl-phenyl)-piperazin-1-yl]-eth...) Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(CC1)c1ccccc1C1CC1 Show InChI InChI=1S/C24H33N3O2/c28-22-17-24(9-3-4-10-24)18-23(29)27(22)16-13-25-11-14-26(15-12-25)21-6-2-1-5-20(21)19-7-8-19/h1-2,5-6,19H,3-4,7-18H2	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.34	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Recordati s.p.a. Curated by ChEMBL					Assay Description Binding affinity to the adrenergic receptor alpha-1D of rat aorta				J Med Chem 47: 1900-18 (2004) Article DOI: 10.1021/jm030944+ BindingDB Entry DOI: 10.7270/Q23F4P35
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM50143681 (8-{2-[4-(2-Cyclopropyl-phenyl)-piperazin-1-yl]-eth...) Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(CC1)c1ccccc1C1CC1 Show InChI InChI=1S/C24H33N3O2/c28-22-17-24(9-3-4-10-24)18-23(29)27(22)16-13-25-11-14-26(15-12-25)21-6-2-1-5-20(21)19-7-8-19/h1-2,5-6,19H,3-4,7-18H2	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Recordati s.p.a. Curated by ChEMBL					Assay Description In vitro binding affinity towards alpha-1A adrenergic receptor through displacement of [3H]-prazosin in epididymal rat vas deferens.				J Med Chem 47: 1900-18 (2004) Article DOI: 10.1021/jm030944+ BindingDB Entry DOI: 10.7270/Q23F4P35
					More data for this Ligand-Target Pair
Adrenergic alpha1B (Homo sapiens (Human))	BDBM50143681 (8-{2-[4-(2-Cyclopropyl-phenyl)-piperazin-1-yl]-eth...) Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(CC1)c1ccccc1C1CC1 Show InChI InChI=1S/C24H33N3O2/c28-22-17-24(9-3-4-10-24)18-23(29)27(22)16-13-25-11-14-26(15-12-25)21-6-2-1-5-20(21)19-7-8-19/h1-2,5-6,19H,3-4,7-18H2	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	35.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Recordati s.p.a. Curated by ChEMBL					Assay Description Binding affinity constant against alpha-1B adrenergic receptor of guinea pig spleen				J Med Chem 47: 1900-18 (2004) Article DOI: 10.1021/jm030944+ BindingDB Entry DOI: 10.7270/Q23F4P35
					More data for this Ligand-Target Pair