BDBM50144806 7-Chloro-3-hydroxy-1H-quinazoline-2,4-dione::7-chloro-3-hydroxyquinazoline-2,4-dione::CHEMBL80594

SMILES: On1c(=O)[nH]c2cc(Cl)ccc2c1=O

InChI Key: InChIKey=CRTPJJNXJPKDEZ-UHFFFAOYSA-N

Data: 5 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50144806   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Carbonic anhydrase (Homo sapiens (Human))	BDBM50144806 (7-Chloro-3-hydroxy-1H-quinazoline-2,4-dione | 7-ch...) Show SMILES On1c(=O)[nH]c2cc(Cl)ccc2c1=O Show InChI InChI=1S/C8H5ClN2O3/c9-4-1-2-5-6(3-4)10-8(13)11(14)7(5)12/h1-3,14H,(H,10,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of recombinant human carbonic anhydrase 12 preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay				J Med Chem 60: 6428-6439 (2017) Article DOI: 10.1021/acs.jmedchem.7b00766 BindingDB Entry DOI: 10.7270/Q2GT5QG3
					More data for this Ligand-Target Pair
Carbonic anhydrases; II & IX (Homo sapiens (Human))	BDBM50144806 (7-Chloro-3-hydroxy-1H-quinazoline-2,4-dione | 7-ch...) Show SMILES On1c(=O)[nH]c2cc(Cl)ccc2c1=O Show InChI InChI=1S/C8H5ClN2O3/c9-4-1-2-5-6(3-4)10-8(13)11(14)7(5)12/h1-3,14H,(H,10,13)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of recombinant human carbonic anhydrase 9 preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay				J Med Chem 60: 6428-6439 (2017) Article DOI: 10.1021/acs.jmedchem.7b00766 BindingDB Entry DOI: 10.7270/Q2GT5QG3
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50144806 (7-Chloro-3-hydroxy-1H-quinazoline-2,4-dione | 7-ch...) Show SMILES On1c(=O)[nH]c2cc(Cl)ccc2c1=O Show InChI InChI=1S/C8H5ClN2O3/c9-4-1-2-5-6(3-4)10-8(13)11(14)7(5)12/h1-3,14H,(H,10,13)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	240	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita' degli Studi di Firenze Curated by ChEMBL					Assay Description Ability of compound to displace [3H]-glycine from N-methyl-D-aspartate glutamate receptor 1 from in cerebral cortex synaptic membranes				Bioorg Med Chem Lett 14: 2345-9 (2004) Article DOI: 10.1016/j.bmcl.2004.01.109 BindingDB Entry DOI: 10.7270/Q29W0DZW
					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50144806 (7-Chloro-3-hydroxy-1H-quinazoline-2,4-dione | 7-ch...) Show SMILES On1c(=O)[nH]c2cc(Cl)ccc2c1=O Show InChI InChI=1S/C8H5ClN2O3/c9-4-1-2-5-6(3-4)10-8(13)11(14)7(5)12/h1-3,14H,(H,10,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay				J Med Chem 60: 6428-6439 (2017) Article DOI: 10.1021/acs.jmedchem.7b00766 BindingDB Entry DOI: 10.7270/Q2GT5QG3
					More data for this Ligand-Target Pair
Carbonic anhydrase (Homo sapiens (Human))	BDBM50144806 (7-Chloro-3-hydroxy-1H-quinazoline-2,4-dione | 7-ch...) Show SMILES On1c(=O)[nH]c2cc(Cl)ccc2c1=O Show InChI InChI=1S/C8H5ClN2O3/c9-4-1-2-5-6(3-4)10-8(13)11(14)7(5)12/h1-3,14H,(H,10,13)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay				J Med Chem 60: 6428-6439 (2017) Article DOI: 10.1021/acs.jmedchem.7b00766 BindingDB Entry DOI: 10.7270/Q2GT5QG3
					More data for this Ligand-Target Pair