BDBM50145465 (Z)-5-(4-Benzyloxybenzylidene)thiazolidine-2,4-dione::5-[1-(4-Benzyloxy-phenyl)-meth-(Z)-ylidene]-thiazolidine-2,4-dione::CHEMBL315736::US8637558, 44
SMILES: OC1=NC(=O)C(S1)=Cc1ccc(OCc2ccccc2)cc1
InChI Key: InChIKey=NITHMFXIRVGRJD-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein-tyrosine phosphatase 1B (Homo sapiens (Human)) | BDBM50145465 ((Z)-5-(4-Benzyloxybenzylidene)thiazolidine-2,4-dio...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Inha University Curated by ChEMBL | Assay Description Inhibition of PTP1B | Bioorg Med Chem Lett 19: 6161-5 (2009) Article DOI: 10.1016/j.bmcl.2009.09.020 BindingDB Entry DOI: 10.7270/Q20P102S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
15-hydroxyprostaglandin dehydrogenase [NAD+] (Homo sapiens (Human)) | BDBM50145465 ((Z)-5-(4-Benzyloxybenzylidene)thiazolidine-2,4-dio...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 1.04E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Industry-Academic Cooperation Foundation, Chosun University US Patent | Assay Description Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s... | US Patent US8637558 (2014) BindingDB Entry DOI: 10.7270/Q280519F | |||||||||||
More data for this Ligand-Target Pair |