BDBM50146453 (E)-3-(4-Methoxy-phenyl)-acrylic acid::3-(4-methoxyphenyl)acrylic acid::4-Methoxycinnamic acid::CHEMBL95770::para-methoxycinnamic acid

SMILES: COc1ccc(\C=C\C(O)=O)cc1

InChI Key: InChIKey=AFDXODALSZRGIH-QPJJXVBHSA-N

Data: 10 IC50

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50146453   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosinase (Agaricus bisporus (Common mushroom))	BDBM50146453 ((E)-3-(4-Methoxy-phenyl)-acrylic acid | 3-(4-metho...) Show SMILES COc1ccc(\C=C\C(O)=O)cc1 Show InChI InChI=1S/C10H10O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-7H,1H3,(H,11,12)/b7-4+	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.10E+5	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of mushroom tyrosinase				Eur J Med Chem 44: 1773-8 (2009) Article DOI: 10.1016/j.ejmech.2008.04.002 BindingDB Entry DOI: 10.7270/Q2DB81M9
					More data for this Ligand-Target Pair
Tyrosinase (Agaricus bisporus (Common mushroom))	BDBM50146453 ((E)-3-(4-Methoxy-phenyl)-acrylic acid | 3-(4-metho...) Show SMILES COc1ccc(\C=C\C(O)=O)cc1 Show InChI InChI=1S/C10H10O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-7H,1H3,(H,11,12)/b7-4+	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.10E+5	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of mushroom tyrosinase assessed as 3,4-dihydroxy-L-phenylalanine oxidation				Bioorg Med Chem Lett 18: 6490-3 (2008) Article DOI: 10.1016/j.bmcl.2008.10.056 BindingDB Entry DOI: 10.7270/Q2959HFK
					More data for this Ligand-Target Pair
Tyrosinase (Agaricus bisporus (Common mushroom))	BDBM50146453 ((E)-3-(4-Methoxy-phenyl)-acrylic acid | 3-(4-metho...) Show SMILES COc1ccc(\C=C\C(O)=O)cc1 Show InChI InChI=1S/C10H10O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-7H,1H3,(H,11,12)/b7-4+	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.10E+5	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of mushroom tyrosinase				Eur J Med Chem 44: 4235-43 (2009) Article DOI: 10.1016/j.ejmech.2009.05.023 BindingDB Entry DOI: 10.7270/Q2PC32DZ
					More data for this Ligand-Target Pair
Tyrosinase (Agaricus bisporus (Common mushroom))	BDBM50146453 ((E)-3-(4-Methoxy-phenyl)-acrylic acid | 3-(4-metho...) Show SMILES COc1ccc(\C=C\C(O)=O)cc1 Show InChI InChI=1S/C10H10O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-7H,1H3,(H,11,12)/b7-4+	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>3.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Kinki University Curated by ChEMBL					Assay Description Inhibition of mushroom tyrosinase after 25 mins by spectrophotometry				Bioorg Med Chem Lett 21: 1983-6 (2011) Article DOI: 10.1016/j.bmcl.2011.02.028 BindingDB Entry DOI: 10.7270/Q2T43TCF
					More data for this Ligand-Target Pair
Alpha-glucosidase MAL62 (Saccharomyces cerevisiae)	BDBM50146453 ((E)-3-(4-Methoxy-phenyl)-acrylic acid | 3-(4-metho...) Show SMILES COc1ccc(\C=C\C(O)=O)cc1 Show InChI InChI=1S/C10H10O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-7H,1H3,(H,11,12)/b7-4+	Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	4.00E+10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of baker's yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate by spectrophotometry				Citation and Details Article DOI: 10.1007/s00044-011-9938-0 BindingDB Entry DOI: 10.7270/Q29W0JBG
					More data for this Ligand-Target Pair
Tyrosinase (Agaricus bisporus (Common mushroom))	BDBM50146453 ((E)-3-(4-Methoxy-phenyl)-acrylic acid | 3-(4-metho...) Show SMILES COc1ccc(\C=C\C(O)=O)cc1 Show InChI InChI=1S/C10H10O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-7H,1H3,(H,11,12)/b7-4+	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.10E+5	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-Sen University Curated by ChEMBL					Assay Description Inhibition of mashroom tyrosinase assessed as oxidation of L-DOPA by spectrophotometry				Eur J Med Chem 45: 639-46 (2010) Article DOI: 10.1016/j.ejmech.2009.11.007 BindingDB Entry DOI: 10.7270/Q2348M9F
					More data for this Ligand-Target Pair
Tyrosinase (Agaricus bisporus (Common mushroom))	BDBM50146453 ((E)-3-(4-Methoxy-phenyl)-acrylic acid | 3-(4-metho...) Show SMILES COc1ccc(\C=C\C(O)=O)cc1 Show InChI InChI=1S/C10H10O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-7H,1H3,(H,11,12)/b7-4+	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	4.10E+5	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of mushroom tyrosinase				Bioorg Med Chem 16: 1096-102 (2008) BindingDB Entry DOI: 10.7270/Q2RF5VWT
					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50146453 ((E)-3-(4-Methoxy-phenyl)-acrylic acid | 3-(4-metho...) Show SMILES COc1ccc(\C=C\C(O)=O)cc1 Show InChI InChI=1S/C10H10O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-7H,1H3,(H,11,12)/b7-4+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	7.60E+5	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Binding affinity towards HSV-1 thymidine kinase				Eur J Med Chem 132: 1-10 (2017) Article DOI: 10.1016/j.ejmech.2017.03.023 BindingDB Entry DOI: 10.7270/Q2WS8WNX
					More data for this Ligand-Target Pair
Carbonic anhydrases; II & IX (Homo sapiens (Human))	BDBM50146453 ((E)-3-(4-Methoxy-phenyl)-acrylic acid | 3-(4-metho...) Show SMILES COc1ccc(\C=C\C(O)=O)cc1 Show InChI InChI=1S/C10H10O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-7H,1H3,(H,11,12)/b7-4+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	8.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Binding affinity towards HSV-1 thymidine kinase				Eur J Med Chem 132: 1-10 (2017) Article DOI: 10.1016/j.ejmech.2017.03.023 BindingDB Entry DOI: 10.7270/Q2WS8WNX
					More data for this Ligand-Target Pair
Tyrosinase (Agaricus bisporus (Common mushroom))	BDBM50146453 ((E)-3-(4-Methoxy-phenyl)-acrylic acid | 3-(4-metho...) Show SMILES COc1ccc(\C=C\C(O)=O)cc1 Show InChI InChI=1S/C10H10O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-7H,1H3,(H,11,12)/b7-4+	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.10E+5	n/a	n/a	n/a	n/a	n/a	n/a
Shaoyang University Curated by ChEMBL					Assay Description Inhibition of diphenolase activity of mushroom tyrosinase preincubated with compound for 10 mins before addition of L-DOPA as substrate by spectropho...				Bioorg Med Chem Lett 21: 2376-9 (2011) Article DOI: 10.1016/j.bmcl.2011.02.076 BindingDB Entry DOI: 10.7270/Q2SF2WG1
					More data for this Ligand-Target Pair