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BDBM50147976 2-(R)-Cyclohexyl-2-guanidino-N-{2-oxo-2-[4-(5-phenyl-2H-pyrazol-3-yl)-piperidin-1-yl]-ethyl}-acetamide::CHEMBL106698

SMILES: NC(N)=N[C@H](C1CCCCC1)C(=O)NCC(=O)N1CCC(CC1)c1cc(n[nH]1)-c1ccccc1

InChI Key: InChIKey=FZWVIIDKIBNWGP-HSZRJFAPSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50147976   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interleukin-2 receptor alpha chain


(Mus musculus)		BDBM50147976
PNG
(2-(R)-Cyclohexyl-2-guanidino-N-{2-oxo-2-[4-(5-phen...)
Show SMILES NC(N)=N[C@H](C1CCCCC1)C(=O)NCC(=O)N1CCC(CC1)c1cc(n[nH]1)-c1ccccc1 |wD:4.3,(11.97,-.63,;11.27,.74,;12.09,2.04,;9.73,.81,;8.91,-.5,;9.61,-1.87,;11.15,-1.92,;11.85,-3.3,;11.03,-4.59,;9.49,-4.52,;8.78,-3.16,;7.37,-.43,;6.65,.92,;6.54,-1.73,;5,-1.68,;4.18,-2.97,;4.9,-4.34,;2.64,-2.91,;1.82,-4.21,;.29,-4.15,;-.42,-2.78,;.38,-1.48,;1.92,-1.55,;-1.96,-2.71,;-2.91,-3.93,;-4.36,-3.39,;-4.31,-1.87,;-2.82,-1.45,;-5.64,-4.25,;-6.99,-3.48,;-8.32,-4.25,;-8.32,-5.79,;-6.99,-6.56,;-5.64,-5.79,)|
Show InChI InChI=1S/C25H35N7O2/c26-25(27)29-23(19-9-5-2-6-10-19)24(34)28-16-22(33)32-13-11-18(12-14-32)21-15-20(30-31-21)17-7-3-1-4-8-17/h1,3-4,7-8,15,18-19,23H,2,5-6,9-14,16H2,(H,28,34)(H,30,31)(H4,26,27,29)/t23-/m1/s1
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n/an/a 1.20E+5n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay

J Med Chem 47: 3111-30 (2004)


Article DOI: 10.1021/jm049967u
BindingDB Entry DOI: 10.7270/Q2TQ6280
More data for this
Ligand-Target Pair