BDBM50148071 (-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6-one(Cyprodime)::17-cyclopropylmethyl-10-hydroxy-4,14-dimethoxy-(1S,9R,10S)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3-dien-6-one(cyprodime)::17-cyclopropylmethyl-3,10-dimethoxy-(1R,9R,10S)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-one::CHEMBL322796::CYPRODIME BROMIDE::Naltrindole analogue::cyprodime
SMILES: COc1cccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)CC[C@@]34OC)c12
InChI Key: InChIKey=INUCRGMCKDQKNA-CEMLEFRQSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mu-type opioid receptor (Rattus norvegicus (rat)) | BDBM50148071 ((-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Medicine& Dentistry of New Jersey-Robert Wood Johnson Medical School (UMDNJ-RWJMS) Curated by ChEMBL | Assay Description Binding affinity against Opioid receptor mu 1 from rat brain membranes using [3H]DAMGO | J Med Chem 48: 1620-9 (2005) Checked by Author Article DOI: 10.1021/jm049117e BindingDB Entry DOI: 10.7270/Q2ZP47MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Homo sapiens (Human)) | BDBM50148071 ((-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity to mu opioid receptor (unknown origin) | J Med Chem 56: 9156-69 (2013) Article DOI: 10.1021/jm4012214 BindingDB Entry DOI: 10.7270/Q2JH3Q4C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (GUINEA PIG) | BDBM50148071 ((-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6...) | UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Innsbruck Curated by ChEMBL | Assay Description Binding affinity was evaluated by measuring the ability to displace [3H]DAMGO radioligand binding from Opioid receptor mu 1 in guinea pig brain membr... | J Med Chem 38: 3071-7 (1995) BindingDB Entry DOI: 10.7270/Q2QJ7HZ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (GUINEA PIG) | BDBM50148071 ((-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6...) | UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity by its ability to displace [3H]DAMGO from mu receptor in homogenates of guinea pig brain | Bioorg Med Chem Lett 5: 1923-1926 (1995) Article DOI: 10.1016/0960-894X(95)00325-N BindingDB Entry DOI: 10.7270/Q2FX79XF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig)) | BDBM50148071 ((-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | 61 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity by its ability to displace [3H]-U-69,593 from kappa receptor in homogenates of guinea pig brain | Bioorg Med Chem Lett 5: 1923-1926 (1995) Article DOI: 10.1016/0960-894X(95)00325-N BindingDB Entry DOI: 10.7270/Q2FX79XF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Delta-type opioid receptor (Homo sapiens (Human)) | BDBM50148071 ((-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 61 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Innsbruck Curated by ChEMBL | Assay Description In vivo binding affinity was evaluated by measuring the ability to displace [3H]DPDPE radioligand binding from delta opioid receptor in guinea pig br... | J Med Chem 38: 3071-7 (1995) BindingDB Entry DOI: 10.7270/Q2QJ7HZ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig)) | BDBM50148071 ((-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 105 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Innsbruck Curated by ChEMBL | Assay Description In vivo binding affinity was evaluated by measuring the ability to displace [3H]U-69593 radioligand binding from Opioid receptor kappa 1 in guinea pi... | J Med Chem 38: 3071-7 (1995) BindingDB Entry DOI: 10.7270/Q2QJ7HZ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Delta-type opioid receptor (Homo sapiens (Human)) | BDBM50148071 ((-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | 105 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity by its ability to displace [3H]DPDPE from delta receptor in homogenates of guinea pig brain | Bioorg Med Chem Lett 5: 1923-1926 (1995) Article DOI: 10.1016/0960-894X(95)00325-N BindingDB Entry DOI: 10.7270/Q2FX79XF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig)) | BDBM50148071 ((-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Medicine& Dentistry of New Jersey-Robert Wood Johnson Medical School (UMDNJ-RWJMS) Curated by ChEMBL | Assay Description Binding affinity against Opioid receptor kappa 1 from guinea pig brain membranes using [3H]U-69593 | J Med Chem 48: 1620-9 (2005) Checked by Author Article DOI: 10.1021/jm049117e BindingDB Entry DOI: 10.7270/Q2ZP47MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Opioid receptors; mu & delta (Rattus norvegicus (rat)) | BDBM50148071 ((-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 417 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Medicine& Dentistry of New Jersey-Robert Wood Johnson Medical School (UMDNJ-RWJMS) Curated by ChEMBL | Assay Description Binding affinity against Opioid receptor delta 1 from rat brain membranes using [3H]DADLE | J Med Chem 48: 1620-9 (2005) Checked by Author Article DOI: 10.1021/jm049117e BindingDB Entry DOI: 10.7270/Q2ZP47MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Rattus norvegicus (rat)) | BDBM50148071 ((-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.06E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Innsbruck Curated by ChEMBL | Assay Description Binding affinity determined by displacing [3H]DAMGO from Opioid receptor mu 1 in rat brain membranes | J Med Chem 47: 3242-7 (2004) Article DOI: 10.1021/jm031126k BindingDB Entry DOI: 10.7270/Q2TD9WT4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Rattus norvegicus (rat)) | BDBM50148071 ((-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.09E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Innsbruck Curated by ChEMBL | Assay Description Binding affinity determined by displacing [3H]U69,593 from Opioid receptor kappa 1 in rat brain membranes | J Med Chem 47: 3242-7 (2004) Article DOI: 10.1021/jm031126k BindingDB Entry DOI: 10.7270/Q2TD9WT4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Opioid receptors; mu & delta (Rattus norvegicus (rat)) | BDBM50148071 ((-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 4.14E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Innsbruck Curated by ChEMBL | Assay Description Binding affinity determined by displacing [3H][Ile5,6]deltorphin II from opioid receptor delta 1 in rat brain membranes | J Med Chem 47: 3242-7 (2004) Article DOI: 10.1021/jm031126k BindingDB Entry DOI: 10.7270/Q2TD9WT4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50148071 ((-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 117 | n/a | n/a | n/a | n/a |
University of Innsbruck Curated by ChEMBL | Assay Description Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human Opioid receptor kappa 1 ex... | J Med Chem 47: 3242-7 (2004) Article DOI: 10.1021/jm031126k BindingDB Entry DOI: 10.7270/Q2TD9WT4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Delta-type opioid receptor (Homo sapiens (Human)) | BDBM50148071 ((-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.11E+3 | n/a | n/a | n/a | n/a |
University of Innsbruck Curated by ChEMBL | Assay Description Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human opioid receptor delta 1 ex... | J Med Chem 47: 3242-7 (2004) Article DOI: 10.1021/jm031126k BindingDB Entry DOI: 10.7270/Q2TD9WT4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Opioid receptor (Rattus norvegicus (rat)-RAT) | BDBM50148071 ((-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Innsbruck Curated by ChEMBL | Assay Description Inhibition of [3H]naloxone binding to opioid receptor in presence of NaCl | J Med Chem 32: 418-21 (1989) BindingDB Entry DOI: 10.7270/Q2ZG6VG1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Opioid receptor (Rattus norvegicus (rat)-RAT) | BDBM50148071 ((-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Innsbruck Curated by ChEMBL | Assay Description Inhibition of [3H]naloxone binding to opioid receptor in presence of NaCl | J Med Chem 32: 418-21 (1989) BindingDB Entry DOI: 10.7270/Q2ZG6VG1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Homo sapiens (Human)) | BDBM50148071 ((-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
University of Innsbruck Curated by ChEMBL | Assay Description Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human Opioid receptor mu 1 expre... | J Med Chem 47: 3242-7 (2004) Article DOI: 10.1021/jm031126k BindingDB Entry DOI: 10.7270/Q2TD9WT4 | |||||||||||
More data for this Ligand-Target Pair |