BDBM50148667 3-(4-Fluoro-phenyl)-2-(6-trifluoromethyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole::3-(4-fluorophenyl)-2-(6-(trifluoromethyl)pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole::CHEMBL333798

SMILES: Fc1ccc(cc1)-c1c2CCCn2nc1-c1cccc(n1)C(F)(F)F

InChI Key: InChIKey=JFQHZKYTJUOQDK-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50148667   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50148667 (3-(4-Fluoro-phenyl)-2-(6-trifluoromethyl-pyridin-2...) Show SMILES Fc1ccc(cc1)-c1c2CCCn2nc1-c1cccc(n1)C(F)(F)F Show InChI InChI=1S/C18H13F4N3/c19-12-8-6-11(7-9-12)16-14-4-2-10-25(14)24-17(16)13-3-1-5-15(23-13)18(20,21)22/h1,3,5-9H,2,4,10H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratory Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38				Bioorg Med Chem Lett 14: 3585-8 (2004) Article DOI: 10.1016/j.bmcl.2004.04.065 BindingDB Entry DOI: 10.7270/Q23R0SCK
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50148667 (3-(4-Fluoro-phenyl)-2-(6-trifluoromethyl-pyridin-2...) Show SMILES Fc1ccc(cc1)-c1c2CCCn2nc1-c1cccc(n1)C(F)(F)F Show InChI InChI=1S/C18H13F4N3/c19-12-8-6-11(7-9-12)16-14-4-2-10-25(14)24-17(16)13-3-1-5-15(23-13)18(20,21)22/h1,3,5-9H,2,4,10H2	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	877	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of TGFR1				Eur J Med Chem 44: 4259-65 (2009) Article DOI: 10.1016/j.ejmech.2009.07.008 BindingDB Entry DOI: 10.7270/Q2BC3ZM9
					More data for this Ligand-Target Pair
Thyroid hormone receptor beta (Homo sapiens (Human))	BDBM50148667 (3-(4-Fluoro-phenyl)-2-(6-trifluoromethyl-pyridin-2...) Show SMILES Fc1ccc(cc1)-c1c2CCCn2nc1-c1cccc(n1)C(F)(F)F Show InChI InChI=1S/C18H13F4N3/c19-12-8-6-11(7-9-12)16-14-4-2-10-25(14)24-17(16)13-3-1-5-15(23-13)18(20,21)22/h1,3,5-9H,2,4,10H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	877	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratory Curated by ChEMBL					Assay Description Inhibitory activity against TGF-beta type I receptor				Bioorg Med Chem Lett 14: 3585-8 (2004) Article DOI: 10.1016/j.bmcl.2004.04.065 BindingDB Entry DOI: 10.7270/Q23R0SCK
					More data for this Ligand-Target Pair