BDBM50148761 CHEMBL3142920::[1-[2',5'-Bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3-N-[3-[[[(methoxycarbonyl)methoxyphosphonyl]-oxy]propyl]thymine]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)

SMILES: COC(=O)P(=O)(OC)OCCCn1c(=O)c(C)cn([C@@H]2O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@]3(OS(=O)(=O)C=C3N)[C@H]2O[Si](C)(C)C(C)(C)C)c1=O

InChI Key: InChIKey=DLNDONLSMKZXLS-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50148761   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50148761 (CHEMBL3142920 | [1-[2',5'-Bis-O-(tert-butyldimethy...) Show SMILES COC(=O)P(=O)(OC)OCCCn1c(=O)c(C)cn([C@@H]2O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@]3(OS(=O)(=O)C=C3N)[C@H]2O[Si](C)(C)C(C)(C)C)c1=O |r,c:36| Show InChI InChI=1S/C30H54N3O13PSSi2/c1-20-17-33(26(35)32(24(20)34)15-14-16-42-47(37,41-9)27(36)40-8)25-23(45-50(12,13)29(5,6)7)30(21(31)19-48(38,39)46-30)22(44-25)18-43-49(10,11)28(2,3)4/h17,19,22-23,25H,14-16,18,31H2,1-13H3	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Química Médica (C.S.I.C.) Curated by ChEMBL					Assay Description Inhibitory concentration against wild type HIV-1/138Lys reverse transcriptase (RT) using [3H]dGTP as a radioligand				J Med Chem 47: 3418-26 (2004) Article DOI: 10.1021/jm031045o BindingDB Entry DOI: 10.7270/Q2B857KW
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50148761 (CHEMBL3142920 | [1-[2',5'-Bis-O-(tert-butyldimethy...) Show SMILES COC(=O)P(=O)(OC)OCCCn1c(=O)c(C)cn([C@@H]2O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@]3(OS(=O)(=O)C=C3N)[C@H]2O[Si](C)(C)C(C)(C)C)c1=O |r,c:36| Show InChI InChI=1S/C30H54N3O13PSSi2/c1-20-17-33(26(35)32(24(20)34)15-14-16-42-47(37,41-9)27(36)40-8)25-23(45-50(12,13)29(5,6)7)30(21(31)19-48(38,39)46-30)22(44-25)18-43-49(10,11)28(2,3)4/h17,19,22-23,25H,14-16,18,31H2,1-13H3	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Química Médica (C.S.I.C.) Curated by ChEMBL					Assay Description Inhibitory concentration against wild type HIV-1 reverse transcriptase (RT) using poly rC.dG as the template or primer				J Med Chem 47: 3418-26 (2004) Article DOI: 10.1021/jm031045o BindingDB Entry DOI: 10.7270/Q2B857KW
					More data for this Ligand-Target Pair