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BDBM50148895 Butyl-[3-(2,4-dimethoxy-phenyl)-2,5-dimethyl-3H-pyrazolo[1,5-a]pyrimidin-7-yl]-ethyl-amine::CHEMBL121286

SMILES: CCCCN(CC)c1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1OC

InChI Key: InChIKey=SKSYONCOYHIRFE-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50148895   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50148895
PNG
(Butyl-[3-(2,4-dimethoxy-phenyl)-2,5-dimethyl-3H-py...)
Show SMILES CCCCN(CC)c1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1OC |(18.13,-14.85,;18.17,-13.31,;16.86,-12.51,;16.91,-10.98,;15.58,-10.16,;15.63,-8.62,;14.32,-7.82,;14.24,-10.9,;14.19,-12.44,;12.82,-13.19,;12.78,-14.72,;11.5,-12.37,;11.55,-10.83,;10.45,-9.75,;11.12,-8.36,;10.39,-7.01,;12.65,-8.58,;12.92,-10.09,;8.94,-10.02,;8.42,-11.46,;6.91,-11.74,;5.9,-10.56,;4.4,-10.83,;3.88,-12.28,;6.44,-9.11,;7.95,-8.85,;8.48,-7.38,;7.49,-6.21,)|
Show InChI InChI=1S/C22H30N4O2/c1-7-9-12-25(8-2)20-13-15(3)23-22-21(16(4)24-26(20)22)18-11-10-17(27-5)14-19(18)28-6/h10-11,13-14H,7-9,12H2,1-6H3
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Article
PubMed
 1.90n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to the cloned human corticotropin releasing factor receptor 1

Bioorg Med Chem Lett 14: 3669-73 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.019
BindingDB Entry DOI: 10.7270/Q2T72GWP
More data for this
Ligand-Target Pair