BDBM50149077 6-[2-(5-Bromo-thiophen-2-yl)-1H-benzoimidazol-5-yl]-4-methyl-4,5-dihydro-2H-pyridazin-3-one::CHEMBL124427

SMILES: CC1CC(=NNC1=O)c1ccc2nc([nH]c2c1)-c1ccc(Br)s1

InChI Key: InChIKey=ZUHSHMSFEYULCI-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50149077   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor X (Homo sapiens (Human))	BDBM50149077 (6-[2-(5-Bromo-thiophen-2-yl)-1H-benzoimidazol-5-yl...) Show SMILES CC1CC(=NNC1=O)c1ccc2nc([nH]c2c1)-c1ccc(Br)s1 |c:3| Show InChI InChI=1S/C16H13BrN4OS/c1-8-6-11(20-21-16(8)22)9-2-3-10-12(7-9)19-15(18-10)13-4-5-14(17)23-13/h2-5,7-8H,6H2,1H3,(H,18,19)(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	980	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Binding affinity of the compoumd to human coagulation factor Xa				Bioorg Med Chem Lett 14: 3763-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.097 BindingDB Entry DOI: 10.7270/Q25H7FQS
					More data for this Ligand-Target Pair
Trypsin-1 (Homo sapiens (Human))	BDBM50149077 (6-[2-(5-Bromo-thiophen-2-yl)-1H-benzoimidazol-5-yl...) Show SMILES CC1CC(=NNC1=O)c1ccc2nc([nH]c2c1)-c1ccc(Br)s1 |c:3| Show InChI InChI=1S/C16H13BrN4OS/c1-8-6-11(20-21-16(8)22)9-2-3-10-12(7-9)19-15(18-10)13-4-5-14(17)23-13/h2-5,7-8H,6H2,1H3,(H,18,19)(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Binding affinity of the compoumd against human trypsin was determined				Bioorg Med Chem Lett 14: 3763-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.097 BindingDB Entry DOI: 10.7270/Q25H7FQS
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50149077 (6-[2-(5-Bromo-thiophen-2-yl)-1H-benzoimidazol-5-yl...) Show SMILES CC1CC(=NNC1=O)c1ccc2nc([nH]c2c1)-c1ccc(Br)s1 |c:3| Show InChI InChI=1S/C16H13BrN4OS/c1-8-6-11(20-21-16(8)22)9-2-3-10-12(7-9)19-15(18-10)13-4-5-14(17)23-13/h2-5,7-8H,6H2,1H3,(H,18,19)(H,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Binding affinity against human thrombin.				Bioorg Med Chem Lett 14: 3763-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.097 BindingDB Entry DOI: 10.7270/Q25H7FQS
					More data for this Ligand-Target Pair