BDBM50149819 2-Amino-4-[1-amino-2-(4-methoxy-phenyl)-ethyl]-6-(2-hydroxy-phenyl)-nicotinonitrile::CHEMBL365281

SMILES: COc1ccc(CC(N)c2cc(nc(N)c2C#N)-c2ccccc2O)cc1

InChI Key: InChIKey=UKEISMOMLMVVOL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50149819   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human))	BDBM50149819 (2-Amino-4-[1-amino-2-(4-methoxy-phenyl)-ethyl]-6-(...) Show SMILES COc1ccc(CC(N)c2cc(nc(N)c2C#N)-c2ccccc2O)cc1 Show InChI InChI=1S/C21H20N4O2/c1-27-14-8-6-13(7-9-14)10-18(23)16-11-19(25-21(24)17(16)12-22)15-4-2-3-5-20(15)26/h2-9,11,18,26H,10,23H2,1H3,(H2,24,25)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto 619-0216 Curated by ChEMBL					Assay Description Inhibitory activity against recombinant human I-kappa-B-kinase beta				Bioorg Med Chem Lett 14: 4013-7 (2004) Article DOI: 10.1016/j.bmcl.2004.05.040 BindingDB Entry DOI: 10.7270/Q2PC31VC
					More data for this Ligand-Target Pair