BDBM50150237 CHEMBL3770914

SMILES: [H][C@@]12CCC[C@]1([H])N1C3N(Cc4ccc(nc4)C(F)(F)F)NC(Nc4ccccc4)=C3C(=O)N(C)C1=N2

InChI Key: InChIKey=KAKDYTFXVBPNSJ-LXMSXWCSSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50150237   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM50150237 (CHEMBL3770914) Show SMILES [H][C@@]12CCC[C@]1([H])N1C3N(Cc4ccc(nc4)C(F)(F)F)NC(Nc4ccccc4)=C3C(=O)N(C)C1=N2 |r,c:32,40| Show InChI InChI=1S/C24H24F3N7O/c1-32-22(35)19-20(29-15-6-3-2-4-7-15)31-33(13-14-10-11-18(28-12-14)24(25,26)27)21(19)34-17-9-5-8-16(17)30-23(32)34/h2-4,6-7,10-12,16-17,21,29,31H,5,8-9,13H2,1H3/t16-,17+,21?/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Intra-Cellular Therapies, Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant full lenght human PDE4A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assay				J Med Chem 59: 1149-64 (2016) BindingDB Entry DOI: 10.7270/Q2X068W7
					More data for this Ligand-Target Pair