BDBM50150512 CHEMBL3769926
SMILES: Cc1cn(cn1)-c1ccc2Nc3nc(Cc4ccccc4)ccc3C(=O)Nc2c1
InChI Key: InChIKey=GRMCXFXAFGCXTM-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50150512 (CHEMBL3769926) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of CYP3A4 (unknown origin) by fluorescence assay | Bioorg Med Chem Lett 26: 1498-502 (2016) BindingDB Entry DOI: 10.7270/Q2CZ3910 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50150512 (CHEMBL3769926) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Modulation of gamma secretase in human H4 cells assessed as inhibition of amyloid beta (1 to 42) production | Bioorg Med Chem Lett 26: 1498-502 (2016) BindingDB Entry DOI: 10.7270/Q2CZ3910 | |||||||||||
More data for this Ligand-Target Pair |