BDBM50151352 5-(6-Methyl-[1,5]naphthyridin-4-yl)-4-pyridin-2-yl-thiazol-2-ylamine::5-(6-methyl-1,5-naphthyridin-4-yl)-4-(pyridin-2-yl)thiazol-2-amine::CHEMBL425177

SMILES: Cc1ccc2nccc(-c3sc(N)nc3-c3ccccn3)c2n1

InChI Key: InChIKey=QXPCZCMDSKNVRW-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50151352   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50151352 (5-(6-Methyl-[1,5]naphthyridin-4-yl)-4-pyridin-2-yl...) Show SMILES Cc1ccc2nccc(-c3sc(N)nc3-c3ccccn3)c2n1 Show InChI InChI=1S/C17H13N5S/c1-10-5-6-13-14(21-10)11(7-9-20-13)16-15(22-17(18)23-16)12-4-2-3-8-19-12/h2-9H,1H3,(H2,18,22)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cells				J Med Chem 47: 4494-506 (2004) Article DOI: 10.1021/jm0400247 BindingDB Entry DOI: 10.7270/Q2VQ325T
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50151352 (5-(6-Methyl-[1,5]naphthyridin-4-yl)-4-pyridin-2-yl...) Show SMILES Cc1ccc2nccc(-c3sc(N)nc3-c3ccccn3)c2n1 Show InChI InChI=1S/C17H13N5S/c1-10-5-6-13-14(21-10)11(7-9-20-13)16-15(22-17(18)23-16)12-4-2-3-8-19-12/h2-9H,1H3,(H2,18,22)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of TGFR1				Eur J Med Chem 44: 4259-65 (2009) Article DOI: 10.1016/j.ejmech.2009.07.008 BindingDB Entry DOI: 10.7270/Q2BC3ZM9
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50151352 (5-(6-Methyl-[1,5]naphthyridin-4-yl)-4-pyridin-2-yl...) Show SMILES Cc1ccc2nccc(-c3sc(N)nc3-c3ccccn3)c2n1 Show InChI InChI=1S/C17H13N5S/c1-10-5-6-13-14(21-10)11(7-9-20-13)16-15(22-17(18)23-16)12-4-2-3-8-19-12/h2-9H,1H3,(H2,18,22)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (0.180-0.790)				J Med Chem 47: 4494-506 (2004) Article DOI: 10.1021/jm0400247 BindingDB Entry DOI: 10.7270/Q2VQ325T
					More data for this Ligand-Target Pair