BDBM50151405 CHEMBL3775211::US10189819, Example 79
SMILES: Cc1ncn(n1)-c1cc(Cl)c(C(=O)NC[C@@H](c2cccc(F)c2)c2cc(F)c3[nH]c(C)nc3c2)c(Cl)c1
InChI Key: InChIKey=QUUULBGFFCEQRH-IBGZPJMESA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Coagulation factor IX (Homo sapiens (Human)) | BDBM50151405 (CHEMBL3775211 | US10189819, Example 79) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of human factor 9a using CH3SO2-DCHG-Gly-Arg-AFC.AcOH as substrate preinubated for 30 mins followed by substrate addition measured after 1... | J Med Chem 59: 1818-29 (2016) BindingDB Entry DOI: 10.7270/Q29Z96S8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor IX (Homo sapiens (Human)) | BDBM50151405 (CHEMBL3775211 | US10189819, Example 79) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 6.42 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme, Corp.; Mochida Paraceuticals Co., Ltd. US Patent | Assay Description Formation of a clot to stem bleeding at a site of blood vessel injury involves the coordinated activity of a group of plasma proteins that initiate a... | US Patent US10189819 (2019) BindingDB Entry DOI: 10.7270/Q200046Z | |||||||||||
More data for this Ligand-Target Pair |