BDBM50151526 CHEMBL363097::N-(4-{5-[(Z)-Cyclohexylimino]-4-methyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl}-phenyl)-acetamide::US8637528, OM956
SMILES: CC(=O)Nc1ccc(cc1)-c1nn(C)\c(=N\C2CCCCC2)s1
InChI Key: InChIKey=HMLIQWYFUWNFED-ZPHPHTNESA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphodiesterase 7 (Homo sapiens (Human)) | BDBM50151526 (CHEMBL363097 | N-(4-{5-[(Z)-Cyclohexylimino]-4-met...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 140 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Omeros Corporation US Patent | Assay Description The assay method used was a scintillation proximity assay (SPA) (obtained from GE Healthcare, Product Code TRKQ7100), with [3H]-cGMP as the substrate... | US Patent US8637528 (2014) BindingDB Entry DOI: 10.7270/Q29022FT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 7 (Homo sapiens (Human)) | BDBM50151526 (CHEMBL363097 | N-(4-{5-[(Z)-Cyclohexylimino]-4-met...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells | Bioorg Med Chem Lett 14: 4607-13 (2004) Article DOI: 10.1016/j.bmcl.2004.07.008 BindingDB Entry DOI: 10.7270/Q2377855 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human)) | BDBM50151526 (CHEMBL363097 | N-(4-{5-[(Z)-Cyclohexylimino]-4-met...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.43E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells | Bioorg Med Chem Lett 14: 4607-13 (2004) Article DOI: 10.1016/j.bmcl.2004.07.008 BindingDB Entry DOI: 10.7270/Q2377855 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 7B (Homo sapiens (Human)) | BDBM50151526 (CHEMBL363097 | N-(4-{5-[(Z)-Cyclohexylimino]-4-met...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 144 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Omeros Corporation US Patent | Assay Description The assay method used was a scintillation proximity assay (SPA) (obtained from GE Healthcare, Product Code TRKQ7100), with [3H]-cGMP as the substrate... | US Patent US8637528 (2014) BindingDB Entry DOI: 10.7270/Q29022FT | |||||||||||
More data for this Ligand-Target Pair |