BDBM50151605 4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',2'',3'',4''-tetrahydroquinazoline)]-6-yl]phenyl-4-methylhexahydro-1-pyrazinylmethanone::CHEMBL183465
SMILES: CN1CCN(CC1)C(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1
InChI Key: InChIKey=UNFGOVWIPVJXET-UHFFFAOYSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphodiesterase 1 (Homo sapiens (Human)) | BDBM50151605 (4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description In vitro inhibition of human Phosphodiesterase 1 partially purified from THP-1 cells | Bioorg Med Chem Lett 14: 4623-6 (2004) Article DOI: 10.1016/j.bmcl.2004.07.011 BindingDB Entry DOI: 10.7270/Q2ZG6RQX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM50151605 (4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.93E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of human Phosphodiesterase 5 | Bioorg Med Chem Lett 14: 4623-6 (2004) Article DOI: 10.1016/j.bmcl.2004.07.011 BindingDB Entry DOI: 10.7270/Q2ZG6RQX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human)) | BDBM50151605 (4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description In vitro inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells | Bioorg Med Chem Lett 14: 4623-6 (2004) Article DOI: 10.1016/j.bmcl.2004.07.011 BindingDB Entry DOI: 10.7270/Q2ZG6RQX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 3 (PDE3) (Homo sapiens (Human)) | BDBM50151605 (4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.93E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description In vitro inhibition of human Phosphodiesterase 3A3 expressed in baculovirus infected Sf9 cells | Bioorg Med Chem Lett 14: 4623-6 (2004) Article DOI: 10.1016/j.bmcl.2004.07.011 BindingDB Entry DOI: 10.7270/Q2ZG6RQX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 7 (Homo sapiens (Human)) | BDBM50151605 (4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description In vitro inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells | Bioorg Med Chem Lett 14: 4623-6 (2004) Article DOI: 10.1016/j.bmcl.2004.07.011 BindingDB Entry DOI: 10.7270/Q2ZG6RQX | |||||||||||
More data for this Ligand-Target Pair |