BDBM50151907 3-(5-Pyridin-2-yl-tetrazol-2-yl)-benzonitrile::CHEMBL365499

SMILES: N#Cc1cccc(c1)-n1nnc(n1)-c1ccccn1

InChI Key: InChIKey=OGIBYDWBTRKAOL-UHFFFAOYSA-N

Data: 4 KI  3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50151907   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50151907 (3-(5-Pyridin-2-yl-tetrazol-2-yl)-benzonitrile | CH...) Show SMILES N#Cc1cccc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C13H8N6/c14-9-10-4-3-5-11(8-10)19-17-13(16-18-19)12-6-1-2-7-15-12/h1-8H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	102	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...				Bioorg Med Chem Lett 14: 5481-4 (2004) Article DOI: 10.1016/j.bmcl.2004.09.018 BindingDB Entry DOI: 10.7270/Q25M657V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50151907 (3-(5-Pyridin-2-yl-tetrazol-2-yl)-benzonitrile | CH...) Show SMILES N#Cc1cccc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C13H8N6/c14-9-10-4-3-5-11(8-10)19-17-13(16-18-19)12-6-1-2-7-15-12/h1-8H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	186	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...				Bioorg Med Chem Lett 14: 5473-6 (2004) Article DOI: 10.1016/j.bmcl.2004.09.012 BindingDB Entry DOI: 10.7270/Q2F47NMM
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50151907 (3-(5-Pyridin-2-yl-tetrazol-2-yl)-benzonitrile | CH...) Show SMILES N#Cc1cccc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C13H8N6/c14-9-10-4-3-5-11(8-10)19-17-13(16-18-19)12-6-1-2-7-15-12/h1-8H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Ability to displace [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from binding to metabotropic glutamate receptor 5 in rat cortical membranes				Bioorg Med Chem Lett 15: 5061-4 (2005) Article DOI: 10.1016/j.bmcl.2005.07.062 BindingDB Entry DOI: 10.7270/Q2GT5MQ0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50151907 (3-(5-Pyridin-2-yl-tetrazol-2-yl)-benzonitrile | CH...) Show SMILES N#Cc1cccc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C13H8N6/c14-9-10-4-3-5-11(8-10)19-17-13(16-18-19)12-6-1-2-7-15-12/h1-8H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from glutamate 5 receptor of rat cortical membranes				J Med Chem 47: 4645-8 (2004) Article DOI: 10.1021/jm049828c BindingDB Entry DOI: 10.7270/Q2DJ5F3G
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50151907 (3-(5-Pyridin-2-yl-tetrazol-2-yl)-benzonitrile | CH...) Show SMILES N#Cc1cccc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C13H8N6/c14-9-10-4-3-5-11(8-10)19-17-13(16-18-19)12-6-1-2-7-15-12/h1-8H	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist				Bioorg Med Chem Lett 14: 5473-6 (2004) Article DOI: 10.1016/j.bmcl.2004.09.012 BindingDB Entry DOI: 10.7270/Q2F47NMM
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50151907 (3-(5-Pyridin-2-yl-tetrazol-2-yl)-benzonitrile | CH...) Show SMILES N#Cc1cccc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C13H8N6/c14-9-10-4-3-5-11(8-10)19-17-13(16-18-19)12-6-1-2-7-15-12/h1-8H	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory concentration towards human glutamate receptor 5 in calcium flux assay				J Med Chem 47: 4645-8 (2004) Article DOI: 10.1021/jm049828c BindingDB Entry DOI: 10.7270/Q2DJ5F3G
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50151907 (3-(5-Pyridin-2-yl-tetrazol-2-yl)-benzonitrile | CH...) Show SMILES N#Cc1cccc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C13H8N6/c14-9-10-4-3-5-11(8-10)19-17-13(16-18-19)12-6-1-2-7-15-12/h1-8H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro functional activity measured by changes in cytosolic [Ca2+] concentrations against rat metabotropic glutamate receptor 5				Bioorg Med Chem Lett 15: 5061-4 (2005) Article DOI: 10.1016/j.bmcl.2005.07.062 BindingDB Entry DOI: 10.7270/Q2GT5MQ0
					More data for this Ligand-Target Pair