BDBM50152193 CHEMBL187649::N-(3-Aminomethyl-phenyl)-2-{3-[(6-amino-2-methyl-pyridin-3-ylmethyl)-amino]-5-chloro-6-methyl-2-oxo-2H-pyrazin-1-yl}-acetamide; TFA

SMILES: Cc1nc(N)ccc1CNc1nc(Cl)c(C)n(CC(=O)Nc2cccc(CN)c2)c1=O

InChI Key: InChIKey=GHDHYMAKAWHTGL-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50152193   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptase (Homo sapiens (Human))	BDBM50152193 (CHEMBL187649 | N-(3-Aminomethyl-phenyl)-2-{3-[(6-a...) Show SMILES Cc1nc(N)ccc1CNc1nc(Cl)c(C)n(CC(=O)Nc2cccc(CN)c2)c1=O Show InChI InChI=1S/C21H24ClN7O2/c1-12-15(6-7-17(24)26-12)10-25-20-21(31)29(13(2)19(22)28-20)11-18(30)27-16-5-3-4-14(8-16)9-23/h3-8H,9-11,23H2,1-2H3,(H2,24,26)(H,25,28)(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	580	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aventis Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory activity against human Tryptase beta 2 expressed in yeast cells				Bioorg Med Chem Lett 14: 4819-23 (2004) Article DOI: 10.1016/j.bmcl.2004.07.051 BindingDB Entry DOI: 10.7270/Q2H994NZ
					More data for this Ligand-Target Pair