BDBM50152199 CHEMBL183942::N-(3-Aminomethyl-phenyl)-2-(5-chloro-6-methyl-2-oxo-3-phenethylamino-2H-pyrazin-1-yl)-acetamide; TFA

SMILES: Cc1c(Cl)nc(NCCc2ccccc2)c(=O)n1CC(=O)Nc1cccc(CN)c1

InChI Key: InChIKey=BKJLSLLPQAKDES-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50152199   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptase (Homo sapiens (Human))	BDBM50152199 (CHEMBL183942 | N-(3-Aminomethyl-phenyl)-2-(5-chlor...) Show SMILES Cc1c(Cl)nc(NCCc2ccccc2)c(=O)n1CC(=O)Nc1cccc(CN)c1 Show InChI InChI=1S/C22H24ClN5O2/c1-15-20(23)27-21(25-11-10-16-6-3-2-4-7-16)22(30)28(15)14-19(29)26-18-9-5-8-17(12-18)13-24/h2-9,12H,10-11,13-14,24H2,1H3,(H,25,27)(H,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.55E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aventis Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory activity against human Tryptase beta 2 expressed in yeast cells				Bioorg Med Chem Lett 14: 4819-23 (2004) Article DOI: 10.1016/j.bmcl.2004.07.051 BindingDB Entry DOI: 10.7270/Q2H994NZ
					More data for this Ligand-Target Pair