BDBM50152200 CHEMBL183528::N-(3-Aminomethyl-phenyl)-2-{5-chloro-6-methyl-2-oxo-3-[(piperidin-4-ylmethyl)-amino]-2H-pyrazin-1-yl}-acetamide; TFA

SMILES: Cc1c(Cl)nc(NCC2CCNCC2)c(=O)n1CC(=O)Nc1cccc(CN)c1

InChI Key: InChIKey=UPTLBLRIQLXTMC-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50152200   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptase (Homo sapiens (Human))	BDBM50152200 (CHEMBL183528 | N-(3-Aminomethyl-phenyl)-2-{5-chlor...) Show SMILES Cc1c(Cl)nc(NCC2CCNCC2)c(=O)n1CC(=O)Nc1cccc(CN)c1 Show InChI InChI=1S/C20H27ClN6O2/c1-13-18(21)26-19(24-11-14-5-7-23-8-6-14)20(29)27(13)12-17(28)25-16-4-2-3-15(9-16)10-22/h2-4,9,14,23H,5-8,10-12,22H2,1H3,(H,24,26)(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aventis Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory activity against human Tryptase beta 2 expressed in yeast cells				Bioorg Med Chem Lett 14: 4819-23 (2004) Article DOI: 10.1016/j.bmcl.2004.07.051 BindingDB Entry DOI: 10.7270/Q2H994NZ
					More data for this Ligand-Target Pair