BDBM50152201 CHEMBL187651::N-(3-Aminomethyl-phenyl)-2-[5-chloro-3-(4-methoxy-benzylamino)-6-methyl-2-oxo-2H-pyrazin-1-yl]-acetamide; TFA

SMILES: COc1ccc(CNc2nc(Cl)c(C)n(CC(=O)Nc3cccc(CN)c3)c2=O)cc1

InChI Key: InChIKey=ANECGPPPUHXIPH-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50152201   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptase (Homo sapiens (Human))	BDBM50152201 (CHEMBL187651 | N-(3-Aminomethyl-phenyl)-2-[5-chlor...) Show SMILES COc1ccc(CNc2nc(Cl)c(C)n(CC(=O)Nc3cccc(CN)c3)c2=O)cc1 Show InChI InChI=1S/C22H24ClN5O3/c1-14-20(23)27-21(25-12-15-6-8-18(31-2)9-7-15)22(30)28(14)13-19(29)26-17-5-3-4-16(10-17)11-24/h3-10H,11-13,24H2,1-2H3,(H,25,27)(H,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.55E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aventis Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory activity against human Tryptase beta 2 expressed in yeast cells				Bioorg Med Chem Lett 14: 4819-23 (2004) Article DOI: 10.1016/j.bmcl.2004.07.051 BindingDB Entry DOI: 10.7270/Q2H994NZ
					More data for this Ligand-Target Pair