BDBM50152204 CHEMBL360210::N-(3-Aminomethyl-phenyl)-2-[5-chloro-3-(indan-2-ylamino)-6-methyl-2-oxo-2H-pyrazin-1-yl]-acetamide; TFA

SMILES: Cc1c(Cl)nc(NC2Cc3ccccc3C2)c(=O)n1CC(=O)Nc1cccc(CN)c1

InChI Key: InChIKey=OBMQOOSNFCFPBL-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50152204   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptase (Homo sapiens (Human))	BDBM50152204 (CHEMBL360210 | N-(3-Aminomethyl-phenyl)-2-[5-chlor...) Show SMILES Cc1c(Cl)nc(NC2Cc3ccccc3C2)c(=O)n1CC(=O)Nc1cccc(CN)c1 Show InChI InChI=1S/C23H24ClN5O2/c1-14-21(24)28-22(27-19-10-16-6-2-3-7-17(16)11-19)23(31)29(14)13-20(30)26-18-8-4-5-15(9-18)12-25/h2-9,19H,10-13,25H2,1H3,(H,26,30)(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	970	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aventis Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory activity against human Tryptase beta 2 expressed in yeast cells				Bioorg Med Chem Lett 14: 4819-23 (2004) Article DOI: 10.1016/j.bmcl.2004.07.051 BindingDB Entry DOI: 10.7270/Q2H994NZ
					More data for this Ligand-Target Pair