BDBM50152371 4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid pyridin-4-ylamide::CHEMBL184180

SMILES: COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=S)Nc1ccncc1

InChI Key: InChIKey=QLHXHYVKFSCNHC-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50152371   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50152371 (4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazol...) Show SMILES COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=S)Nc1ccncc1 Show InChI InChI=1S/C27H35N7O2S/c1-35-24-18-22-23(19-25(24)36-17-5-12-32-10-3-2-4-11-32)29-20-30-26(22)33-13-15-34(16-14-33)27(37)31-21-6-8-28-9-7-21/h6-9,18-20H,2-5,10-17H2,1H3,(H,28,31,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
and In Vivo Sciences Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description In vitro inhibition of Platelet derived growth factor receptor beta autophosphorylation in MG-63 cells without plasma				Bioorg Med Chem Lett 14: 4867-72 (2004) Article DOI: 10.1016/j.bmcl.2004.07.041 BindingDB Entry DOI: 10.7270/Q2VM4BQN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50152371 (4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazol...) Show SMILES COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=S)Nc1ccncc1 Show InChI InChI=1S/C27H35N7O2S/c1-35-24-18-22-23(19-25(24)36-17-5-12-32-10-3-2-4-11-32)29-20-30-26(22)33-13-15-34(16-14-33)27(37)31-21-6-8-28-9-7-21/h6-9,18-20H,2-5,10-17H2,1H3,(H,28,31,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	580	n/a	n/a	n/a	n/a	n/a	n/a
and In Vivo Sciences Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Platelet derived growth factor receptor beta autophosphorylation in CHO cells				Bioorg Med Chem Lett 14: 4867-72 (2004) Article DOI: 10.1016/j.bmcl.2004.07.041 BindingDB Entry DOI: 10.7270/Q2VM4BQN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50152371 (4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazol...) Show SMILES COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=S)Nc1ccncc1 Show InChI InChI=1S/C27H35N7O2S/c1-35-24-18-22-23(19-25(24)36-17-5-12-32-10-3-2-4-11-32)29-20-30-26(22)33-13-15-34(16-14-33)27(37)31-21-6-8-28-9-7-21/h6-9,18-20H,2-5,10-17H2,1H3,(H,28,31,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
and In Vivo Sciences Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description In vitro inhibition of Platelet derived growth factor receptor beta autophosphorylation in MG-63 cells with 45% human plasma				Bioorg Med Chem Lett 14: 4867-72 (2004) Article DOI: 10.1016/j.bmcl.2004.07.041 BindingDB Entry DOI: 10.7270/Q2VM4BQN
					More data for this Ligand-Target Pair