BDBM50152488 8-[1-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-pyrrolidin-3-yloxy]-quinolin-2-ylamine::CHEMBL362501

SMILES: Nc1ccc2cccc(OC3CCN(C3)c3ccc4OCCOc4c3)c2n1

InChI Key: InChIKey=BBYRQKZFHKDPAA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50152488   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanin-concentrating hormone receptor (Homo sapiens (Human))	BDBM50152488 (8-[1-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-pyrrolidi...) Show SMILES Nc1ccc2cccc(OC3CCN(C3)c3ccc4OCCOc4c3)c2n1 Show InChI InChI=1S/C21H21N3O3/c22-20-7-4-14-2-1-3-18(21(14)23-20)27-16-8-9-24(13-16)15-5-6-17-19(12-15)26-11-10-25-17/h1-7,12,16H,8-11,13H2,(H2,22,23)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes				Bioorg Med Chem Lett 14: 4883-6 (2004) Article DOI: 10.1016/j.bmcl.2004.07.035 BindingDB Entry DOI: 10.7270/Q2GB23H4
					More data for this Ligand-Target Pair