BDBM50152718 3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-[2-(methyl-phenyl-amino)-thiazol-4-yl]-1H-pyrimidine-2,4-dione::CHEMBL367812

SMILES: CN(c1nc(cs1)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](N)c2ccccc2)c1=O)c1ccccc1

InChI Key: InChIKey=MJRSTEUAPLZJTR-VWLOTQADSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50152718   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gonadotropin releasing hormone 1 (GnRHR1) (Homo sapiens (Human))	BDBM50152718 (3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-ben...) Show SMILES CN(c1nc(cs1)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](N)c2ccccc2)c1=O)c1ccccc1 Show InChI InChI=1S/C30H27F2N5O2S/c1-19-27(26-18-40-29(34-26)35(2)21-12-7-4-8-13-21)28(38)37(17-25(33)20-10-5-3-6-11-20)30(39)36(19)16-22-23(31)14-9-15-24(22)32/h3-15,18,25H,16-17,33H2,1-2H3/t25-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	34	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Binding affinity towards cloned human Gonadotropin-releasing hormone receptor expressed in RBL cells was determined by using [125I]-GnRH as radioliga...				Bioorg Med Chem Lett 14: 4967-73 (2004) Article DOI: 10.1016/j.bmcl.2004.07.022 BindingDB Entry DOI: 10.7270/Q2FF3RT4
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