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BDBM50153172 6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)methyl)-3'-(trifluoromethoxy)biphenyl-3-carbonitrile::6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethyl]-3''-trifluoromethoxy-biphenyl-3-carbonitrile::6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethoxymethyl]-3'-trifluoromethoxy-biphenyl-3-carbonitrile::CHEMBL181748

SMILES: FC(F)(F)Oc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N

InChI Key: InChIKey=IGCOPNHCHHWZNH-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50153172   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (Human))
BDBM50153172
PNG
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)36-25-3-1-2-22(11-25)26-10-21(13-32)8-9-23(26)16-35-17-24-14-33-18-34(24)15-20-6-4-19(12-31)5-7-20/h1-11,14,18H,15-17H2
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.370n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ras CVIM by human Farnesyltransferase


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50153172
PNG
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)36-25-3-1-2-22(11-25)26-10-21(13-32)8-9-23(26)16-35-17-24-14-33-18-34(24)15-20-6-4-19(12-31)5-7-20/h1-11,14,18H,15-17H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.490n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of bovine farnesyltransferase


Bioorg Med Chem Lett 14: 5371-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8
More data for this
Ligand-Target Pair
Geranylgeranyl Transferase (GGTase-I)


(Bos taurus (bovine))
BDBM50153172
PNG
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)36-25-3-1-2-22(11-25)26-10-21(13-32)8-9-23(26)16-35-17-24-14-33-18-34(24)15-20-6-4-19(12-31)5-7-20/h1-11,14,18H,15-17H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 990n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of bovine Geranylgeranyltransferase


Bioorg Med Chem Lett 14: 5371-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50153172
PNG
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)36-25-3-1-2-22(11-25)26-10-21(13-32)8-9-23(26)16-35-17-24-14-33-18-34(24)15-20-6-4-19(12-31)5-7-20/h1-11,14,18H,15-17H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 990n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-GGPP incorporation into C-terminus of K-Ras by human Geranylgeranyl transferase type I


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair