null

SMILES: Cc1c(Br)cc(Br)c(NC(=O)CN2CCN(CC2)c2ccc(Br)cc2C#N)c1Br

InChI Key: InChIKey=YAGRRKYCTXMYMI-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50153261   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50153261 (2-[4-(4-Bromo-2-cyano-phenyl)-piperazin-1-yl]-N-(2...) Show SMILES Cc1c(Br)cc(Br)c(NC(=O)CN2CCN(CC2)c2ccc(Br)cc2C#N)c1Br Show InChI InChI=1S/C20H18Br4N4O/c1-12-15(22)9-16(23)20(19(12)24)26-18(29)11-27-4-6-28(7-5-27)17-3-2-14(21)8-13(17)10-25/h2-3,8-9H,4-7,11H2,1H3,(H,26,29)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	114	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro ability to inhibit [3H]-6b binding to human Dopamine receptor D4.4				Bioorg Med Chem Lett 14: 5095-8 (2004) Article DOI: 10.1016/j.bmcl.2004.07.068 BindingDB Entry DOI: 10.7270/Q23X863Q
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50153261 (2-[4-(4-Bromo-2-cyano-phenyl)-piperazin-1-yl]-N-(2...) Show SMILES Cc1c(Br)cc(Br)c(NC(=O)CN2CCN(CC2)c2ccc(Br)cc2C#N)c1Br Show InChI InChI=1S/C20H18Br4N4O/c1-12-15(22)9-16(23)20(19(12)24)26-18(29)11-27-4-6-28(7-5-27)17-3-2-14(21)8-13(17)10-25/h2-3,8-9H,4-7,11H2,1H3,(H,26,29)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	936	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro ability to inhibit [3H]-spiperone binding to human Dopamine receptor D4.4				Bioorg Med Chem Lett 14: 5095-8 (2004) Article DOI: 10.1016/j.bmcl.2004.07.068 BindingDB Entry DOI: 10.7270/Q23X863Q
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50153261 (2-[4-(4-Bromo-2-cyano-phenyl)-piperazin-1-yl]-N-(2...) Show SMILES Cc1c(Br)cc(Br)c(NC(=O)CN2CCN(CC2)c2ccc(Br)cc2C#N)c1Br Show InChI InChI=1S/C20H18Br4N4O/c1-12-15(22)9-16(23)20(19(12)24)26-18(29)11-27-4-6-28(7-5-27)17-3-2-14(21)8-13(17)10-25/h2-3,8-9H,4-7,11H2,1H3,(H,26,29)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Agonist activity was calculated in calcium flux assay using HEK-293 cells co-transfected with human Dopamine receptor D4.4 and Galphaqo5				Bioorg Med Chem Lett 14: 5095-8 (2004) Article DOI: 10.1016/j.bmcl.2004.07.068 BindingDB Entry DOI: 10.7270/Q23X863Q
					More data for this Ligand-Target Pair