BDBM50153334 CHEMBL3774545::US10179769, Example 39::US10807956, Example 39::US9611221, Example 39::US9725441, Example 39::US9828343, Example 39
SMILES: Cc1ccc(CNc2cnccc2C(O)=O)s1
InChI Key: InChIKey=RFUZGPWCXINBNW-UHFFFAOYSA-N
Data: 17 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM50153334 (CHEMBL3774545 | US10179769, Example 39 | US1080795...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline R&D Curated by ChEMBL | Assay Description Inhibition of full length human HALO-tagged KDM4C expressed in human U2OS cells assessed as level of H3K9Me3 demethylation incubated overnight by Hoe... | J Med Chem 59: 1357-69 (2016) BindingDB Entry DOI: 10.7270/Q2542QFT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM50153334 (CHEMBL3774545 | US10179769, Example 39 | US1080795...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
CELGENE QUANTICEL RESEARCH, INC. US Patent | Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ... | US Patent US10807956 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 5A (Homo sapiens (Human)) | BDBM50153334 (CHEMBL3774545 | US10179769, Example 39 | US1080795...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c... | US Patent US9611221 (2017) BindingDB Entry DOI: 10.7270/Q26975NT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 5B (Homo sapiens (Human)) | BDBM50153334 (CHEMBL3774545 | US10179769, Example 39 | US1080795...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8... | US Patent US9611221 (2017) BindingDB Entry DOI: 10.7270/Q26975NT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM50153334 (CHEMBL3774545 | US10179769, Example 39 | US1080795...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ... | US Patent US9611221 (2017) BindingDB Entry DOI: 10.7270/Q26975NT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 5A (Homo sapiens (Human)) | BDBM50153334 (CHEMBL3774545 | US10179769, Example 39 | US1080795...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c... | US Patent US9725441 (2017) BindingDB Entry DOI: 10.7270/Q29Z971T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 5B (Homo sapiens (Human)) | BDBM50153334 (CHEMBL3774545 | US10179769, Example 39 | US1080795...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction conditions: 0.8... | US Patent US9725441 (2017) BindingDB Entry DOI: 10.7270/Q29Z971T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM50153334 (CHEMBL3774545 | US10179769, Example 39 | US1080795...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ... | US Patent US9725441 (2017) BindingDB Entry DOI: 10.7270/Q29Z971T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 5A (Homo sapiens (Human)) | BDBM50153334 (CHEMBL3774545 | US10179769, Example 39 | US1080795...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c... | US Patent US10179769 (2019) BindingDB Entry DOI: 10.7270/Q2J38VPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 5B (Homo sapiens (Human)) | BDBM50153334 (CHEMBL3774545 | US10179769, Example 39 | US1080795...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction conditions: 0.8... | US Patent US10179769 (2019) BindingDB Entry DOI: 10.7270/Q2J38VPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 5B (Homo sapiens (Human)) | BDBM50153334 (CHEMBL3774545 | US10179769, Example 39 | US1080795...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ... | US Patent US10179769 (2019) BindingDB Entry DOI: 10.7270/Q2J38VPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 5A (Homo sapiens (Human)) | BDBM50153334 (CHEMBL3774545 | US10179769, Example 39 | US1080795...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description Jarid1A Assay: The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ab... | US Patent US9828343 (2017) BindingDB Entry DOI: 10.7270/Q2ST7S40 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 5B (Homo sapiens (Human)) | BDBM50153334 (CHEMBL3774545 | US10179769, Example 39 | US1080795...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description Jarid1B: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction condit... | US Patent US9828343 (2017) BindingDB Entry DOI: 10.7270/Q2ST7S40 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM50153334 (CHEMBL3774545 | US10179769, Example 39 | US1080795...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio... | US Patent US9828343 (2017) BindingDB Entry DOI: 10.7270/Q2ST7S40 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 5A (Homo sapiens (Human)) | BDBM50153334 (CHEMBL3774545 | US10179769, Example 39 | US1080795...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
CELGENE QUANTICEL RESEARCH, INC. US Patent | Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c... | US Patent US10807956 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 5B (Homo sapiens (Human)) | BDBM50153334 (CHEMBL3774545 | US10179769, Example 39 | US1080795...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
CELGENE QUANTICEL RESEARCH, INC. US Patent | Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384 well plate format under the following reaction conditions: 0.8... | US Patent US10807956 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM50153334 (CHEMBL3774545 | US10179769, Example 39 | US1080795...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline R&D Curated by ChEMBL | Assay Description Inhibition of KDM4C (unknown origin) using H3K9Me3 peptide as substrate assessed as demethylation of substrate by Rapidfire mass spectrometric analys... | J Med Chem 59: 1357-69 (2016) BindingDB Entry DOI: 10.7270/Q2542QFT | |||||||||||
More data for this Ligand-Target Pair |