BDBM50153873 CHEMBL186852::N-{4-Methyl-3-[6-(3-pyrrolidin-1-yl-propylamino)-pyrimidin-4-ylamino]-phenyl}-2-morpholin-4-yl-isonicotinamide

SMILES: Cc1ccc(NC(=O)c2ccnc(c2)N2CCOCC2)cc1Nc1cc(NCCCN2CCCC2)ncn1

InChI Key: InChIKey=TWJSIIMDBNBMSE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50153873   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50153873 (CHEMBL186852 | N-{4-Methyl-3-[6-(3-pyrrolidin-1-yl...) Show SMILES Cc1ccc(NC(=O)c2ccnc(c2)N2CCOCC2)cc1Nc1cc(NCCCN2CCCC2)ncn1 Show InChI InChI=1S/C28H36N8O2/c1-21-5-6-23(33-28(37)22-7-9-30-27(17-22)36-13-15-38-16-14-36)18-24(21)34-26-19-25(31-20-32-26)29-8-4-12-35-10-2-3-11-35/h5-7,9,17-20H,2-4,8,10-16H2,1H3,(H,33,37)(H2,29,31,32,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibitory concentration against alpha mitogen activated protein kinase p38 activity				Bioorg Med Chem Lett 14: 5389-94 (2004) Article DOI: 10.1016/j.bmcl.2004.08.007 BindingDB Entry DOI: 10.7270/Q24Q7TGZ
					More data for this Ligand-Target Pair