BDBM50154387 CHEMBL3774528
SMILES: Cc1sc2ncnc(SCC(O)=O)c2c1Cl
InChI Key: InChIKey=XEVLMTSZUBIPOS-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Palmitoleoyl-protein carboxylesterase NOTUM (Homo sapiens (Human)) | BDBM50154387 (CHEMBL3774528) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 107 | n/a | n/a | n/a | n/a |
Lexicon Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of human notum pectinacetylesterase expressed in 293F cells after 30 mins by TCF/LEF cell sensor assay | Bioorg Med Chem Lett 26: 1525-8 (2016) BindingDB Entry DOI: 10.7270/Q26W9CZZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Palmitoleoyl-protein carboxylesterase NOTUM (Homo sapiens (Human)) | BDBM50154387 (CHEMBL3774528) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Inhibition of human His6-tagged NOTUM (81 to 451 residues) Cys330Ser mutant transfected in HEK293S cells using OPTS as substrate incubated for 1 hr b... | Bioorg Med Chem Lett 30: (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Palmitoleoyl-protein carboxylesterase NOTUM (Mus musculus) | BDBM50154387 (CHEMBL3774528) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 409 | n/a | n/a | n/a | n/a |
Lexicon Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of mouse notum pectinacetylesterase expressed in 293F cells after 30 mins by TCF/LEF cell sensor assay | Bioorg Med Chem Lett 26: 1525-8 (2016) BindingDB Entry DOI: 10.7270/Q26W9CZZ | |||||||||||
More data for this Ligand-Target Pair |