BDBM50155213 1-(5-Cyclobutyl-thiazol-2-yl)-3-isoquinolin-8-yl-urea::CHEMBL186342
SMILES: O=C(Nc1ncc(s1)C1CCC1)Nc1cccc2ccncc12
InChI Key: InChIKey=MEWQZVRRNOXYMJ-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclin-dependent-like kinase 5 (Homo sapiens (Human)) | BDBM50155213 (1-(5-Cyclobutyl-thiazol-2-yl)-3-isoquinolin-8-yl-u...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay | Bioorg Med Chem Lett 14: 5521-5 (2004) Article DOI: 10.1016/j.bmcl.2004.09.006 BindingDB Entry DOI: 10.7270/Q2D50MFB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK2/CycE (Homo sapiens (Human)) | BDBM50155213 (1-(5-Cyclobutyl-thiazol-2-yl)-3-isoquinolin-8-yl-u...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay | Bioorg Med Chem Lett 14: 5521-5 (2004) Article DOI: 10.1016/j.bmcl.2004.09.006 BindingDB Entry DOI: 10.7270/Q2D50MFB | |||||||||||
More data for this Ligand-Target Pair |