BDBM50155962 4-{Ethyl-[4-(4-methoxy-2-methyl-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrido[2,3-b]pyrazin-8-yl]-amino}-butyronitrile::CHEMBL365511

SMILES: CCN(CCCC#N)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(OC)cc1C

InChI Key: InChIKey=URZADVOXNOVKLK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50155962   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50155962 (4-{Ethyl-[4-(4-methoxy-2-methyl-phenyl)-6-methyl-2...) Show SMILES CCN(CCCC#N)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(OC)cc1C Show InChI InChI=1S/C22H27N5O2/c1-5-26(11-7-6-10-23)19-13-16(3)24-22-21(19)25-20(28)14-27(22)18-9-8-17(29-4)12-15(18)2/h8-9,12-13H,5-7,11,14H2,1-4H3,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1				J Med Chem 47: 5783-90 (2004) Article DOI: 10.1021/jm049737f BindingDB Entry DOI: 10.7270/Q2S75FT6
					More data for this Ligand-Target Pair