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SMILES: CCNc1cc(C)nc2N(CC(=O)Nc12)c1ccc(OC)cc1Cl

InChI Key: InChIKey=WHUAURDGIJJOJZ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50155978   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50155978
PNG
(4-(2-Chloro-4-methoxy-phenyl)-8-ethylamino-6-methy...)
Show SMILES CCNc1cc(C)nc2N(CC(=O)Nc12)c1ccc(OC)cc1Cl
Show InChI InChI=1S/C17H19ClN4O2/c1-4-19-13-7-10(2)20-17-16(13)21-15(23)9-22(17)14-6-5-11(24-3)8-12(14)18/h5-8H,4,9H2,1-3H3,(H,19,20)(H,21,23)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1

J Med Chem 47: 5783-90 (2004)


Article DOI: 10.1021/jm049737f
BindingDB Entry DOI: 10.7270/Q2S75FT6
More data for this
Ligand-Target Pair