BDBM50156069 CHEMBL365409::N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-methylbenzamide::N-(2,5-Diphenyl-2H-pyrazol-3-yl)-4-methyl-benzamide

SMILES: Cc1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1

InChI Key: InChIKey=IQSIXTDPSJCEFA-UHFFFAOYSA-N

Data: 1 KI  3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50156069   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50156069 (CHEMBL365409 | N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-...) Show SMILES Cc1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C23H19N3O/c1-17-12-14-19(15-13-17)23(27)24-22-16-21(18-8-4-2-5-9-18)25-26(22)20-10-6-3-7-11-20/h2-16H,1H3,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	780	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Displacement of [3H]methoxyPEPy from rat mGluR5 expressed in HEK293 cells				J Med Chem 49: 3332-44 (2006) Article DOI: 10.1021/jm051252j BindingDB Entry DOI: 10.7270/Q2PR7VK1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50156069 (CHEMBL365409 | N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-...) Show SMILES Cc1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C23H19N3O/c1-17-12-14-19(15-13-17)23(27)24-22-16-21(18-8-4-2-5-9-18)25-26(22)20-10-6-3-7-11-20/h2-16H,1H3,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	64	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes				J Med Chem 49: 3332-44 (2006) Article DOI: 10.1021/jm051252j BindingDB Entry DOI: 10.7270/Q2PR7VK1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50156069 (CHEMBL365409 | N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-...) Show SMILES Cc1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C23H19N3O/c1-17-12-14-19(15-13-17)23(27)24-22-16-21(18-8-4-2-5-9-18)25-26(22)20-10-6-3-7-11-20/h2-16H,1H3,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Effective concentration against metabotropic glutamate receptor 5 of rat				J Med Chem 47: 5825-8 (2004) Article DOI: 10.1021/jm049400d BindingDB Entry DOI: 10.7270/Q2HQ3ZC5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50156069 (CHEMBL365409 | N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-...) Show SMILES Cc1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C23H19N3O/c1-17-12-14-19(15-13-17)23(27)24-22-16-21(18-8-4-2-5-9-18)25-26(22)20-10-6-3-7-11-20/h2-16H,1H3,(H,24,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Effective concentration against metabotropic glutamate receptor 5 of human transfected into CHO cells				J Med Chem 47: 5825-8 (2004) Article DOI: 10.1021/jm049400d BindingDB Entry DOI: 10.7270/Q2HQ3ZC5
					More data for this Ligand-Target Pair