BDBM50156831 CHEMBL373913::N-{4-[5-(4-fluorophenyl)-3-(2-hydroxyethyl)-2-(4-methylsulfinylbenzylsulfanyl)-3H-imidazol-4-yl]pyridin-2-yl}acetamide

SMILES: CC(=O)Nc1cc(ccn1)-c1c(nc(SCc2ccc(cc2)S(C)=O)n1CCO)-c1ccc(F)cc1

InChI Key: InChIKey=DQOSJNXVPIGPDQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50156831   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50156831 (CHEMBL373913 | N-{4-[5-(4-fluorophenyl)-3-(2-hydro...) Show SMILES CC(=O)Nc1cc(ccn1)-c1c(nc(SCc2ccc(cc2)S(C)=O)n1CCO)-c1ccc(F)cc1 Show InChI InChI=1S/C26H25FN4O3S2/c1-17(33)29-23-15-20(11-12-28-23)25-24(19-5-7-21(27)8-6-19)30-26(31(25)13-14-32)35-16-18-3-9-22(10-4-18)36(2)34/h3-12,15,32H,13-14,16H2,1-2H3,(H,28,29,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls-University Tübingen Curated by ChEMBL					Assay Description Inhibition of mitogen-activated protein kinase p38 alpha				J Med Chem 47: 6311-25 (2004) Article DOI: 10.1021/jm0496584 BindingDB Entry DOI: 10.7270/Q2N8799P
					More data for this Ligand-Target Pair