BDBM50156832 CHEMBL374756::N-{4-[3-(2,2-dimethoxyethyl)-5-(4-fluorophenyl)-2-methylsulfanyl3H-imidazol-4-yl]pyridin-2-yl}acetamide

SMILES: COC(Cn1c(SC)nc(c1-c1ccnc(NC(C)=O)c1)-c1ccc(F)cc1)OC

InChI Key: InChIKey=YCBHXBCXNQRSJJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50156832   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50156832 (CHEMBL374756 | N-{4-[3-(2,2-dimethoxyethyl)-5-(4-f...) Show SMILES COC(Cn1c(SC)nc(c1-c1ccnc(NC(C)=O)c1)-c1ccc(F)cc1)OC Show InChI InChI=1S/C21H23FN4O3S/c1-13(27)24-17-11-15(9-10-23-17)20-19(14-5-7-16(22)8-6-14)25-21(30-4)26(20)12-18(28-2)29-3/h5-11,18H,12H2,1-4H3,(H,23,24,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls-University Tübingen Curated by ChEMBL					Assay Description Inhibition of mitogen-activated protein kinase p38 alpha				J Med Chem 47: 6311-25 (2004) Article DOI: 10.1021/jm0496584 BindingDB Entry DOI: 10.7270/Q2N8799P
					More data for this Ligand-Target Pair