BDBM50157426 CHEMBL3780635

SMILES: CN1CCN(CC1)c1ccc(NC(=O)c2c(N)cc[nH]c2=O)cc1

InChI Key: InChIKey=MMNRWYHXYIKIBU-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50157426   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50157426 (CHEMBL3780635) Show SMILES CN1CCN(CC1)c1ccc(NC(=O)c2c(N)cc[nH]c2=O)cc1 Show InChI InChI=1S/C17H21N5O2/c1-21-8-10-22(11-9-21)13-4-2-12(3-5-13)20-17(24)15-14(18)6-7-19-16(15)23/h2-7H,8-11H2,1H3,(H,20,24)(H3,18,19,23)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	346	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human EGFR catalytic domain (668 to 1210 residues) T790M/L858R double mutant using Fl-EEPLYWSFPAKKK-CONH2 peptide substrate preincubate...				ACS Med Chem Lett 7: 100-4 (2016) BindingDB Entry DOI: 10.7270/Q25T3NCC
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50157426 (CHEMBL3780635) Show SMILES CN1CCN(CC1)c1ccc(NC(=O)c2c(N)cc[nH]c2=O)cc1 Show InChI InChI=1S/C17H21N5O2/c1-21-8-10-22(11-9-21)13-4-2-12(3-5-13)20-17(24)15-14(18)6-7-19-16(15)23/h2-7H,8-11H2,1H3,(H,20,24)(H3,18,19,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>2.54E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human N-terminal GST-tagged EGFR catalytic domain (669 to 1210 residues) expressed in baculovirus expression system using Fl-EEPLYWSFPA...				ACS Med Chem Lett 7: 100-4 (2016) BindingDB Entry DOI: 10.7270/Q25T3NCC
					More data for this Ligand-Target Pair