null

SMILES: COC(=O)[C@@H](CC(C)C)NC(=O)N(C[C@@H](O)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1

InChI Key: InChIKey=RARVWDBODUOHND-TWJOJJKGSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50157574   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157574 ((R)-methyl 2-(3-benzyl-3-((2R,3R)-3-(tert-butoxyca...) Show SMILES COC(=O)[C@@H](CC(C)C)NC(=O)N(C[C@@H](O)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1 |r| Show InChI InChI=1S/C30H43N3O6/c1-21(2)17-25(27(35)38-6)31-28(36)33(19-23-15-11-8-12-16-23)20-26(34)24(18-22-13-9-7-10-14-22)32-29(37)39-30(3,4)5/h7-16,21,24-26,34H,17-20H2,1-6H3,(H,31,36)(H,32,37)/t24-,25-,26-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of gamma secretase in CHO cells expressing human APP by ELISA				J Med Chem 47: 6485-9 (2004) Article DOI: 10.1021/jm049566e BindingDB Entry DOI: 10.7270/Q2MK6DP8
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157574 ((R)-methyl 2-(3-benzyl-3-((2R,3R)-3-(tert-butoxyca...) Show SMILES COC(=O)[C@@H](CC(C)C)NC(=O)N(C[C@@H](O)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1 |r| Show InChI InChI=1S/C30H43N3O6/c1-21(2)17-25(27(35)38-6)31-28(36)33(19-23-15-11-8-12-16-23)20-26(34)24(18-22-13-9-7-10-14-22)32-29(37)39-30(3,4)5/h7-16,21,24-26,34H,17-20H2,1-6H3,(H,31,36)(H,32,37)/t24-,25-,26-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of gamma secretase isolated from HeLa cells by ELISA				J Med Chem 47: 6485-9 (2004) Article DOI: 10.1021/jm049566e BindingDB Entry DOI: 10.7270/Q2MK6DP8
					More data for this Ligand-Target Pair