BDBM50157941 CHEMBL3780841

SMILES: COc1ccccc1Nc1cc[nH]c(=O)c1-c1nc2c(cccc2[nH]1)C(C)C

InChI Key: InChIKey=QKOJPEXCCASSHF-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50157941   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50157941 (CHEMBL3780841) Show SMILES COc1ccccc1Nc1cc[nH]c(=O)c1-c1nc2c(cccc2[nH]1)C(C)C Show InChI InChI=1S/C22H22N4O2/c1-13(2)14-7-6-9-17-20(14)26-21(25-17)19-16(11-12-23-22(19)27)24-15-8-4-5-10-18(15)28-3/h4-13H,1-3H3,(H,25,26)(H2,23,24,27)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	58	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human EGFR catalytic domain (668 to 1210 residues) T790M/L858R double mutant using Fl-EEPLYWSFPAKKK-CONH2 peptide substrate preincubate...				ACS Med Chem Lett 7: 100-4 (2016) BindingDB Entry DOI: 10.7270/Q25T3NCC
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50157941 (CHEMBL3780841) Show SMILES COc1ccccc1Nc1cc[nH]c(=O)c1-c1nc2c(cccc2[nH]1)C(C)C Show InChI InChI=1S/C22H22N4O2/c1-13(2)14-7-6-9-17-20(14)26-21(25-17)19-16(11-12-23-22(19)27)24-15-8-4-5-10-18(15)28-3/h4-13H,1-3H3,(H,25,26)(H2,23,24,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human N-terminal GST-tagged EGFR catalytic domain (669 to 1210 residues) expressed in baculovirus expression system using Fl-EEPLYWSFPA...				ACS Med Chem Lett 7: 100-4 (2016) BindingDB Entry DOI: 10.7270/Q25T3NCC
					More data for this Ligand-Target Pair